Biochemistry Center, Heidelberg University, 69120 Heidelberg, Germany; Interdisciplinary Center for Neurosciences, Heidelberg University, 69120 Heidelberg, Germany.
Biochemistry Center, Heidelberg University, 69120 Heidelberg, Germany; Interdisciplinary Center for Neurosciences, Heidelberg University, 69120 Heidelberg, Germany.
Dev Cell. 2018 Apr 9;45(1):10-32. doi: 10.1016/j.devcel.2018.01.023.
A precise communication between the nervous and the vascular systems is crucial for proper formation and function of the central nervous system (CNS). Interestingly, this communication does not only occur by neural cells regulating the growth and properties of the vasculature, but new studies show that blood vessels actively control different neurodevelopmental processes. Here, we review the current knowledge on how neurons in particular influence growing blood vessels during CNS development and on how vessels participate in shaping the neural compartment. We also review the identified molecular mechanisms of this bidirectional communication.
神经系统和血管系统之间的精确通讯对于中枢神经系统（CNS）的正常形成和功能至关重要。有趣的是，这种通讯不仅发生在神经细胞调节血管的生长和特性上，新的研究还表明，血管还积极控制着不同的神经发育过程。在这里，我们回顾了目前关于神经元在 CNS 发育过程中如何影响生长中的血管，以及血管如何参与塑造神经区室的知识。我们还回顾了这种双向通讯的已识别分子机制。
