睾酮对老年小鼠昼夜节律的影响。
Effects of testosterone on circadian rhythmicity in old mice.
机构信息
Laboratory of Animal Physiology, School of Agriculture, Meiji University, 1-1-1 Hgashimita, Tama-ku, Kawasaki, Kanagawa, 214-8571, Japan.
Department of Oral-Chrono Physiology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Nagasaki, 852-8588, Japan.
出版信息
J Physiol Sci. 2019 Sep;69(5):791-798. doi: 10.1007/s12576-019-00695-4. Epub 2019 Jul 12.
Serum testosterone concentration decreases with age in humans and rodents. Accordingly, old male mice show changes in locomotor activity rhythms: a lengthened free-running period and decreased activity levels among others. To investigate whether testosterone replacement improves the age-related decline in circadian rhythmicity, we examined the effects of testosterone on the circadian rhythms of wheel running activity in old male mice. Intact male C57BL/6J mice (18-22 months old) were subcutaneously implanted with silicone tubes packed with testosterone propionate (TP) or cholesterol. TP treatment significantly decreased the daily wheel running revolutions in a normal light/dark (LD) cycle and in constant darkness (DD), but did not affect the free-running period. The same experiment performed on young male gonadectomized mice (3-5 months old) demonstrated that TP treatment significantly increased activity levels in both LD and DD. These results suggest that testosterone replacement exacerbates the age-related decline in circadian rhythmicity.
血清睾丸酮浓度在人类和啮齿动物中随年龄增长而降低。因此，老年雄性小鼠的运动活动节律发生变化：自由运行周期延长，活动水平降低等。为了研究睾丸酮替代是否能改善与年龄相关的昼夜节律下降，我们研究了睾丸酮对老年雄性小鼠轮跑活动昼夜节律的影响。将完整的雄性 C57BL/6J 小鼠（18-22 个月大）皮下植入装有丙酸睾丸酮（TP）或胆固醇的硅酮管。TP 处理显著减少了正常明暗（LD）周期和持续黑暗（DD）中每日的轮跑旋转次数，但对自由运行周期没有影响。在年轻雄性去势小鼠（3-5 个月大）上进行的相同实验表明，TP 处理显著增加了 LD 和 DD 中的活动水平。这些结果表明，睾丸酮替代会加剧与年龄相关的昼夜节律下降。
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