Atlantic Cancer Research Institute, Pavillon Hôtel-Dieu, 35 Providence Street, Moncton, New Brunswick E1C 8X3, Canada.
Faculty of Medicine and Health Sciences, Université de Sherbrooke, 2500 de l'Université Boulevard, Sherbrooke, Québec J1K 2R1, Canada; Centre de formation médicale du Nouveau-Brunswick, 100 Des Aboiteaux Street, Moncton, New Brunswick E1A 7R1, Canada.
Clin Chim Acta. 2019 Oct;497:27-34. doi: 10.1016/j.cca.2019.07.012. Epub 2019 Jul 10.
Extracellular vesicles, small reservoirs that carry various biomolecules, have gained significant interest from the clinical field in recent years based on the diagnostic, therapeutic and prognostic possibilities they offer. While information abound regarding the clinical potential of such vesicles in diverse conditions, the information demonstrating their likely importance in amyotrophic lateral sclerosis (ALS) is more limited. This review will thus provide a brief introduction to extracellular vesicles, highlight their diagnostic significance in various diseases with a focus on ALS and explore additional applications of extracellular vesicles in the medical field. Overall, this work sheds further light on the clinical importance of extracellular vesicles in diagnostic applications as well as supports the need to better characterize their roles and signatures in patients diagnosed with ALS.
细胞外囊泡是一种携带各种生物分子的小容器，近年来因其在诊断、治疗和预后方面的可能性而引起了临床领域的广泛关注。虽然关于此类囊泡在各种疾病中的临床应用潜力的信息很多，但在肌萎缩侧索硬化症（ALS）中证明其重要性的信息则更为有限。因此，本综述将对细胞外囊泡进行简要介绍，重点强调其在各种疾病中的诊断意义，特别是在 ALS 中的诊断意义，并探讨细胞外囊泡在医学领域的其他应用。总的来说，这项工作进一步强调了细胞外囊泡在诊断应用中的临床重要性，并支持需要更好地描述其在被诊断为 ALS 的患者中的作用和特征。
