Ecological Risk Research Division, Korea Institute of Ocean Science and Technology (KIOST), Geoje, 53201, Republic of Korea; The Faculty of Applied Ocean Science, University of Science and Technology (UST), Geoje, 53201, Republic of Korea; Faculty of Fisheries and Marine Science, Brawijaya University, Malang, 65145, Indonesia.
Ecological Risk Research Division, Korea Institute of Ocean Science and Technology (KIOST), Geoje, 53201, Republic of Korea.
Environ Toxicol Pharmacol. 2019 Oct;71:103215. doi: 10.1016/j.etap.2019.103215. Epub 2019 Jul 5.
The extensive use in humans and animals of nonsteroidal anti-inflammatory drugs (NSAIDs) increases their possible impact on aquatic organisms. In the present study, we investigated acute toxicity, morphological responses, and potential physiological and metabolic impacts of naproxen exposure on Hydra magnipapillata. The median lethal concentrations (LC) of naproxen in H. magnipapillata were 51.999 mg/L, 44.935 mg/L, and 42.500 mg/L after exposure for 24, 48, and 72 h, respectively. Morphological observation of the exposed Hydra showed that 40 mg/L naproxen stimulated the contraction of body column and tentacles after 24 h. A KEGG pathway analysis of the genes differentially expressed in the Hydra after exposure to naproxen for 6, 24, or 48 h demonstrated various cellular and metabolic effects, including protein processing in the endoplasmic reticulum, Wnt signaling, and tryptophan metabolism. These results suggest that exposure to naproxen affects the genetic material, inflammatory processes, and metabolic processes of aquatic organisms.
非甾体抗炎药（NSAIDs）在人类和动物中的广泛应用增加了它们对水生生物可能产生的影响。在本研究中，我们研究了萘普生暴露对大水螅（Hydra magnipapillata）的急性毒性、形态反应以及潜在的生理和代谢影响。暴露 24、48 和 72 小时后，萘普生对大水螅的半数致死浓度（LC）分别为 51.999mg/L、44.935mg/L 和 42.500mg/L。暴露后水螅的形态观察显示，40mg/L 的萘普生在 24 小时后刺激了身体柱和触须的收缩。暴露于萘普生 6、24 或 48 小时后，水螅中差异表达基因的 KEGG 途径分析显示了各种细胞和代谢效应，包括内质网中的蛋白质加工、Wnt 信号和色氨酸代谢。这些结果表明，萘普生暴露会影响水生生物的遗传物质、炎症过程和代谢过程。
