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丧偶后,男性是否比女性更容易患上抑郁症?来自三个德国老年队列的证据(AgeDifferent.de 平台)。

Are older men more vulnerable to depression than women after losing their spouse? Evidence from three German old-age cohorts (AgeDifferent.de platform).

机构信息

Institute of Social Medicine, Occupational Health and Public Health (ISAP), University of Leipzig, Germany.

Institute of Social Medicine, Occupational Health and Public Health (ISAP), University of Leipzig, Germany.

出版信息

J Affect Disord. 2019 Sep 1;256:650-657. doi: 10.1016/j.jad.2019.06.047. Epub 2019 Jul 1.

DOI:10.1016/j.jad.2019.06.047
PMID:31301630
Abstract

BACKGROUND

Old age is accompanied by a higher risk of losing a spouse. This study aims to longitudinally investigate the effect of widowhood on depression severity with a special focus on sex differences. We examine depression before and after widowhood in men and women separately to investigate which sex is at greater risk after losing a spouse.

METHODS

Data came from the AgeDifferent.de platform, which includes three pooled old age cohort studies. In order to examine factors associated with depression over time, we applied a linear hybrid mixed-effects regression model for the overall sample and analysed additional separate models for men and women.

RESULTS

Of 2470 respondents (mean age at baseline 79.2 (SD 3.64) years), 1256 were men. In total, 209 men and 332 women experienced spousal bereavement after baseline. In general, both sexes showed higher depression severity after widowhood. However, there were significant sex differences. Widowed men were more prone to subsequent depression than widowed women. In terms of depression severity, widowed men differed significantly compared to non-widowed men; however, this was not the case for women.

LIMITATION

We harmonized three cohort studies which used different measurement scales for depression and different recruitment procedures.

CONCLUSION

Our study showed that although both genders suffer from losing a spouse, men are more prone to subsequently develop depressive symptoms. Raising the awareness among practitioners for sex-specific differences as well as developing tailored interventions for both widowed men and women should be considered.

摘要

背景

随着年龄的增长,丧偶的风险也会增加。本研究旨在纵向探讨丧偶对抑郁严重程度的影响,并特别关注性别差异。我们分别在男性和女性中检查丧偶前后的抑郁情况,以调查哪个性别在丧偶后面临更大的风险。

方法

数据来自 AgeDifferent.de 平台,该平台包含三个老年队列研究的合并数据。为了研究随时间变化与抑郁相关的因素,我们对总体样本应用了线性混合效应回归模型,并为男性和女性分别分析了额外的单独模型。

结果

在 2470 名受访者中(基线时的平均年龄为 79.2(SD 3.64)岁),有 1256 名是男性。共有 209 名男性和 332 名女性在基线后经历了配偶丧亡。总的来说,两性在丧偶后都表现出更高的抑郁严重程度。然而,存在显著的性别差异。丧偶男性比丧偶女性更容易随后出现抑郁。就抑郁严重程度而言,丧偶男性与未丧偶男性有显著差异;然而,女性则不然。

局限性

我们对三个使用不同抑郁测量量表和不同招募程序的队列研究进行了协调。

结论

我们的研究表明,尽管两性都因丧偶而受苦,但男性更容易随后发展出抑郁症状。从业者应提高对性别特异性差异的认识,并为丧偶的男性和女性制定有针对性的干预措施。

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