Klobusická M, Kalafut F, Novotná L
Neoplasma. 1978;25(6):667-77.
The authors have studied the influence of primary, methylcholanthrene-induced tumor on T and B lymphocytes of spleen, thymus, draining lymph nodes and peripheral blood of rats. Differences in weight of tumors were found to correlate with changes in proportionality of T and B lymphocytes of followed organs. Small tumors induced but insignificant changes. There was increased trapping of T lymphocytes in spleen and lymph nodes with simultaneous decrease in peripheral blood. The authors noted a high percentage of blasts. B lymphocytes showed a tendency to compensate for the loss of T cells. Large, progressively growing tumors caused evident exhaustion in the number of both cell types in lymph nodes and peripheral blood. In the spleen there was slower exhaustion. Reduction in the number of B lymphocytes correlated with the size of tumor. Blasts disappeared. Proportionality of T and B lymphocytes in thymus did not appear to be influenced by the size of tumor.
作者研究了原发性甲基胆蒽诱导的肿瘤对大鼠脾脏、胸腺、引流淋巴结和外周血中T淋巴细胞和B淋巴细胞的影响。发现肿瘤重量的差异与后续器官中T淋巴细胞和B淋巴细胞比例的变化相关。诱导产生的小肿瘤引起的变化不显著。脾脏和淋巴结中T淋巴细胞的滞留增加，同时外周血中T淋巴细胞减少。作者注意到母细胞的比例很高。B淋巴细胞显示出补偿T细胞损失的趋势。大的、进行性生长的肿瘤导致淋巴结和外周血中两种细胞类型的数量明显耗尽。脾脏中的耗尽速度较慢。B淋巴细胞数量的减少与肿瘤大小相关。母细胞消失。胸腺中T淋巴细胞和B淋巴细胞的比例似乎不受肿瘤大小的影响。
