Klobusická M, Koníková E
Neoplasma. 1982;29(6):727-34.
Changes in distribution properties of T lymphocytes from lymphoid organs of normal rats 3H-uridine labeled in vitro and i. v. injected to tumor-bearing recipients were studied at different stages of tumor growth and rejection. Comparisons were made with T cell migration from normal donors to syngeneic recipients. A temporary decrease in the ability of normal spleen T lymphocytes to migrate into the spleen of tumor-bearing recipients at early stages of tumor growth was in correlation with their enhancement in trapping by the liver of this recipient. At this stage the migrations into tumor-draining lymph nodes and peripheral blood were rather pronounced. The growing tumor evoked an increased migration rate of donor spleen cells into each of the recipient organs studied except for liver. Tumor rejection potentiated the distribution mainly in the draining lymph node and liver. Normal lymph node T lymphocytes migrated at the beginning of tumor growth into spleen, node and liver of tumor-bearing recipients. A sharp decrease of distribution in spleen at the time of maximum tumor growth was compensated by an enhanced migration into draining nodes, peripheral blood and liver. This enhancement was seen also during tumor rejection. Distribution of normal blood T lymphocytes into spleen and peripheral blood of tumor-bearing recipients was equal to normal values. There was only a transitional reduction in their migration rates into draining nodes caused by tumor growth. Migration rates of thymocytes in tumor-bearing recipients remained unaltered. The results presented indicate that the distribution pattern of i. v. injected labeled T lymphocytes from normal donors into lymphoid organs of tumor-bearing recipients was determined by changes in the immune status of the recipients brought about by tumor development.
研究了在体外经3H-尿苷标记并经静脉注射到荷瘤受体的正常大鼠淋巴器官中T淋巴细胞分布特性在肿瘤生长和排斥不同阶段的变化。并与正常供体T细胞向同基因受体的迁移进行了比较。在肿瘤生长早期，正常脾T淋巴细胞迁移到荷瘤受体脾脏的能力暂时下降，这与其在该受体肝脏中的捕获增强相关。在此阶段，向肿瘤引流淋巴结和外周血的迁移相当明显。生长中的肿瘤使供体脾细胞向除肝脏外的每个研究受体器官的迁移率增加。肿瘤排斥增强了主要在引流淋巴结和肝脏中的分布。正常淋巴结T淋巴细胞在肿瘤生长开始时迁移到荷瘤受体的脾脏、淋巴结和肝脏。在肿瘤生长最大时脾脏分布的急剧减少被向引流淋巴结、外周血和肝脏的迁移增强所补偿。在肿瘤排斥期间也观察到这种增强。正常血液T淋巴细胞在荷瘤受体脾脏和外周血中的分布等于正常值。肿瘤生长仅导致它们向引流淋巴结的迁移率出现短暂降低。荷瘤受体中胸腺细胞的迁移率保持不变。所呈现的结果表明，经静脉注射的来自正常供体的标记T淋巴细胞在荷瘤受体淋巴器官中的分布模式是由肿瘤发展引起的受体免疫状态变化所决定的。
