用于检测抗星状病毒免疫球蛋白M和G的放射免疫测定法的开发与评估。

The development and evaluation of radioimmune assays for the detection of immune globulins M and G against astrovirus.

作者信息

Wilson S A, Cubitt W D

机构信息

Public Health Laboratory, Central Middlesex Hospital, London, U.K.

出版信息

J Virol Methods. 1988 Feb;19(2):151-9. doi: 10.1016/0166-0934(88)90158-9.

DOI:10.1016/0166-0934(88)90158-9

PMID:3130387

Abstract

The development and evaluation of radioimmune assays for the detection of IgM and IgG antibodies to astrovirus are described. The test was shown to be sensitive and specific, and suitable for screening large numbers of sera. The use of the assays has established that astrovirus type 1 is prevalent in the United Kingdom and that not only infants but also schoolchildren and elderly patients are affected. Further evidence is given to support the view that Marin County Agent is antigenically related to astrovirus type 1.

摘要

本文描述了用于检测抗星状病毒IgM和IgG抗体的放射免疫测定法的开发与评估。该检测方法被证明具有敏感性和特异性，适用于筛查大量血清。这些测定法的应用已证实1型星状病毒在英国很普遍，不仅婴儿，而且学童和老年患者也会受到影响。进一步的证据支持了“马林县因子与1型星状病毒在抗原性上相关”这一观点。