使用重组病毒抗原测定伦敦1型和6型星状病毒的血清流行率。
Seroprevalence of astrovirus types 1 and 6 in London, determined using recombinant virus antigen.
作者信息
Kriston S, Willcocks M M, Carter M J, Cubitt W D
机构信息
Department of Virology, Hospital for Children, London.
出版信息
Epidemiol Infect. 1996 Aug;117(1):159-64. doi: 10.1017/s0950268800001266.
Abstract
We have developed a microimmunofluorescence test (IF) which uses cells infected with a recombinant baculovirus which expresses the capsid proteins of astrovirus types 1 or 6. The IF test was sensitive and specific and the results for human astrovirus type 1 (HAst-1) were comparable to those obtained by immune electronmicroscopy and radioimmunoassay. Application of the test to a panel of 273 sera collected from patients and staff at two childrens hospitals in London showed that over 50% of the population were infected by HAst-1 between the age of 5 and 12 months rising to 90% by 5 years, whereas human astrovirus type 6 (HAst6) was relatively uncommon (10-30%) in all age groups.
摘要
我们开发了一种微量免疫荧光试验（IF），该试验使用感染了重组杆状病毒的细胞，该重组杆状病毒表达1型或6型星状病毒的衣壳蛋白。IF试验灵敏且特异，1型人星状病毒（HAst-1）的检测结果与免疫电子显微镜和放射免疫测定法的结果相当。将该试验应用于从伦敦两家儿童医院的患者和工作人员中收集的273份血清样本，结果显示，50%以上的人群在5至12个月大时感染了HAst-1，到5岁时这一比例升至90%，而6型人星状病毒（HAst6）在所有年龄组中相对不常见（10%-30%）。
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