骨关节炎是一种机械性疾病还是炎症性疾病？
Is osteoarthritis a mechanical or inflammatory disease?
作者信息
de Rezende Márcia Uchôa, de Campos Gustavo Constantino
机构信息
Institute of Orthopedics and Traumatology, Hospital das Clínicas, School of Medicine, University of São Paulo, São Paulo, SP, Brazil.
出版信息
Rev Bras Ortop. 2013 Dec 17;48(6):471-474. doi: 10.1016/j.rboe.2013.12.002. eCollection 2013 Nov-Dec.
Traditionally considered "wear and tear" disease, the pathogenic mechanisms of osteoarthritis have not yet been elucidated. The increasing number of articles demonstrating the influence of inflammatory factors in the onset and progression of the disease currently raises great debate in the literature about the importance of each of the factors involved in the disease. Even the choice between the terms "Osteoarthritis" and "Osteoarthrosis" generates controversy, since the first term implies the presence of inflammation as the key generator of the disease, and the latter denotes a degenerative/mechanical causal factor. The aim of this revision article is to promote a debate on the influence of inflammatory factors and mechanical factors in the pathogenesis of OA.
骨关节炎的发病机制传统上被认为是“磨损”性疾病，但至今尚未阐明。越来越多的文章表明炎症因子在该疾病的发生和发展中具有影响，这在文献中引发了关于该疾病所涉及的各个因素重要性的激烈争论。甚至“骨关节炎”和“骨关节病”这两个术语的选择也引发了争议，因为前一个术语意味着炎症是该疾病的关键成因，而后一个术语表示的是一种退行性/机械性致病因素。这篇综述文章的目的是推动关于炎症因子和机械因素在骨关节炎发病机制中的影响的讨论。
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