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从受污染的河流沉积物中收集的DF07基因组数据揭示了一种机会致病菌和一个潜在的抗生素储存库。

Genome data of DF07 collected from polluted river sediment reveals an opportunistic pathogen and a potential antibiotic reservoir.

作者信息

Iyer Rupa, Damania Ashish, Iken Brian

机构信息

Center for Life Sciences Technology, Engineering Technology, University of Houston, Houston, USA.

Department of Pediatrics-Tropical Medicine, Baylor College of Medicine, Houston, USA.

出版信息

Data Brief. 2019 Jun 11;25:104137. doi: 10.1016/j.dib.2019.104137. eCollection 2019 Aug.

Abstract

DF07 is a gram negative bacterium isolated from polluted San Jacinto River sediment near Moncrief Park in Channelview, Texas. The genome of strain DF07 (chromosome and plasmid) was compiled at the scaffold level and can be accessed through the National Center for Biotechnology Information database under accession NZ_NJGC00000000. The DF07 genome consists of a total of 4,801,842 bp encoding for approximately 4,351 functional proteins. Approximately 86 proteins are associated with broad-spectrum antibiotic resistance, 11 are associated with bacteriocin production, and a total of 17 proteins encode for an assortment of -like virulence and invasion operons. DF07 is genetically similar to the nosocomial strain AU12-09, but also harbors an unusually large plasmid that encodes for over 150 proteins of unknown function. Taken together, this strain is potentially an important antibiotic reservoir and its origin within a recreational park merits further study of the area.

摘要

DF07是一种革兰氏阴性菌,从得克萨斯州钱尼尔维尤市蒙克里夫公园附近受污染的圣哈辛托河沉积物中分离出来。DF07菌株的基因组(染色体和质粒)在支架水平上进行了汇编,可通过美国国家生物技术信息中心数据库获取,登录号为NZ_NJGC00000000。DF07基因组总共由4,801,842个碱基对组成,编码约4,351种功能蛋白。大约86种蛋白质与广谱抗生素耐药性相关,11种与细菌素产生相关,共有17种蛋白质编码各种类似毒力和侵袭操纵子。DF07在基因上与医院菌株AU12 - 09相似,但也含有一个异常大的质粒,该质粒编码150多种功能未知的蛋白质。综上所述,该菌株可能是一个重要的抗生素储存库,其在休闲公园内的来源值得对该地区进行进一步研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e218/6600701/4e5c6cac9acf/gr1.jpg

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