Ono T, Wada O, Umemoto S
Tachikawa College of Tokyo, Japan.
J Toxicol Sci. 1987 Nov;12(4):373-81. doi: 10.2131/jts.12.373.
A personal computer was introduced in conditioned lever-press avoidance experiment in Sidman situation. Experimental data were analyzed with both classic indices such as response rate and shock rate and new indices introduced in this experiment. New indices include sum of squares of shock-shock intervals, mean of shock-response time and number of shock-response time less then 5 sec. Results obtained in diazepam-treated mice were consistent with those reported previously by the classic method. In mannitol-treated mice, significant changes of the avoidance behavior could be detected by both the classic index and our new indices. By the new indices other than classic indices, the effect of administration with sodium chloride on the avoidance behavior could be detected, whereas the classic indices could not detect the effect. Though the meanings of these indices i physiological and toxicological aspects should be appreciated in future study, the experimental system reported in this paper might be applicable in the toxicological research to detect the effect of administration with various substances on the avoidance behavior.
在西曼情境的条件性杠杆按压回避实验中引入了一台个人计算机。实验数据使用诸如反应率和电击率等经典指标以及本实验中引入的新指标进行分析。新指标包括电击 - 电击间隔的平方和、电击 - 反应时间的平均值以及小于5秒的电击 - 反应时间的数量。在给予地西泮的小鼠中获得的结果与先前用经典方法报道的结果一致。在给予甘露醇的小鼠中，经典指标和我们的新指标都能检测到回避行为的显著变化。通过除经典指标之外的新指标，可以检测到给予氯化钠对回避行为的影响，而经典指标则无法检测到这种影响。尽管这些指标在生理学和毒理学方面的意义有待在未来研究中进一步明确，但本文报道的实验系统可能适用于毒理学研究，以检测给予各种物质对回避行为的影响。
