Kuribara H
Pharmacol Biochem Behav. 1982 Sep;17(3):425-9. doi: 10.1016/0091-3057(82)90299-4.
Effects of methamphetamine (MAMP), chlorpromazine (CPZ), pilocarpine (PILO) and scopolamine (SCOP) on Sidman avoidance response (response-shock interval = 30 sec, and shock-shock interval=5 sec) were investigated in male rats of Wistar and Fischer 344 strains. The results were compared between the two strains. Both the Wistar and Fischer 344 rats acquired the Sidman avoidance response well and exhibited almost the same baseline response rate (lever-presses/min) of about 6/min and shock rate (number of shocks delivered/min) of about 0.27/min. MAMP and SCOP facilitated the avoidance response with an increase in the response rate and a decrease in the shock rate. CPZ and PILO suppressed the avoidance response with a decrease in the response rate and an increase in the shock rate. The Wistar rats were less sensitive to the avoidance facilitating effect of MAMP, and more sensitive to the avoidance suppressing effect of CPZ than the Fischer 344 rats. In contrast, the Wistar rats were less sensitive to the avoidance suppressing effect of PILO, and more sensitive to the avoidance facilitating effect of SCOP than the Fischer 344 rats. These results suggest that the neural activities of both catecholaminergic and muscarinic-cholinergic systems are different between the Wistar and Fischer 344 rats, and that the two strains rats respond differently to central acting drugs.
在Wistar和Fischer 344品系的雄性大鼠中，研究了甲基苯丙胺（MAMP）、氯丙嗪（CPZ）、毛果芸香碱（PILO）和东莨菪碱（SCOP）对西德曼回避反应（反应-电击间隔 = 30秒，电击-电击间隔 = 5秒）的影响。比较了两个品系的结果。Wistar和Fischer 344大鼠均能很好地获得西德曼回避反应，并且表现出几乎相同的基线反应率（每分钟杠杆按压次数），约为6次/分钟，以及电击率（每分钟给予的电击次数），约为0.27次/分钟。MAMP和SCOP通过提高反应率和降低电击率促进回避反应。CPZ和PILO通过降低反应率和提高电击率抑制回避反应。与Fischer 344大鼠相比，Wistar大鼠对MAMP的回避促进作用较不敏感，而对CPZ的回避抑制作用更敏感。相反，与Fischer 344大鼠相比，Wistar大鼠对PILO的回避抑制作用较不敏感，而对SCOP的回避促进作用更敏感。这些结果表明，Wistar和Fischer 344大鼠的儿茶酚胺能和毒蕈碱胆碱能系统的神经活动均不同，并且这两个品系的大鼠对中枢作用药物的反应也不同。
