弗氏白血病病毒引起的免疫抑制受同种异体反应性T淋巴细胞的H-2限制。
Immunosuppression by Friend leukemia virus is H-2 restricted by alloreactive T lymphocytes.
作者信息
Kumar V, Bennett M
出版信息
Proc Natl Acad Sci U S A. 1979 May;76(5):2415-9. doi: 10.1073/pnas.76.5.2415.
Friend leukemia virus suppresses mitogen-responsive cells in vitro by activating thymus-dependent suppressor cells. The interaction between T suppressor and mitogen-responsive cells is H-2D restricted by a third cell type, called an interfering cell. The interfering cells could be characterized as alloreactive T cells that functionally mature in the spleen at 2 weeks of age and that can be functionally inhibited by mitomycin C, irradiation, and cortisol. Interfering cells are stimulated by H-2D (and not H-2L) alloantigens of the mitogen-responsive cells. H-2D differences between interfering and T suppressor cells are unimportant. Induction of "tolerance" to H-2 alloantigens in semi-allogeneic radiation marrow chimeras resulted in the specific loss of interfering cell function. It is possible that interfering or similar cells participate in other forms of H-2 restriction.
Friend白血病病毒通过激活胸腺依赖性抑制细胞在体外抑制有丝分裂原反应性细胞。抑制性T细胞与有丝分裂原反应性细胞之间的相互作用受第三种细胞类型（称为干扰细胞）的H-2D限制。干扰细胞可被表征为同种异体反应性T细胞，其在2周龄时在脾脏中功能成熟，并且可被丝裂霉素C、辐射和皮质醇功能抑制。干扰细胞受有丝分裂原反应性细胞的H-2D（而非H-2L）同种异体抗原刺激。干扰细胞与抑制性T细胞之间的H-2D差异并不重要。在半同种异体辐射骨髓嵌合体中诱导对H-2同种异体抗原的“耐受性”导致干扰细胞功能的特异性丧失。干扰细胞或类似细胞可能参与其他形式的H-2限制。
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