体外抑制细胞诱导。IV. 抗原特异性抑制因子的靶标及其遗传关系。
Suppressor-cell induction in vitro. IV. Target of antigen-specific suppressor factor and its genetic relationships.
作者信息
Kontiainen S, Feldmann M
出版信息
J Exp Med. 1978 Jan 1;147(1):110-22. doi: 10.1084/jem.147.1.110.
Abstract
Antigen-specific suppressor factor produced by metabolically active in vitro-induced suppressor cells, upon further antigenic stimulation, act on nylon wool nonadherent, Ly-2-negative target cells within helper cell population, resulting in suppression of both the IgM and IgG antibody responses. Thus the target is an Ly-1+ T cell, possibly the helper cell. All the mouse strains tested so far have been able to produce the factor, and when tested in CBA or B10 mice, there seems to be no genetic restriction involved e.g., nonsyngeneic suppressor factors suppress as well as do the syngeneic factors. Comparison of the properties of suppressor factor with those of extracts of suppressor cells yield differences in origin, target of action and effect, indicating that these are different molecules. The heterogeneity of suppressor pathways is discussed.
摘要
由体外诱导的代谢活跃的抑制细胞产生的抗原特异性抑制因子，在进一步受到抗原刺激后，作用于辅助细胞群体中尼龙毛非黏附、Ly-2阴性的靶细胞，导致IgM和IgG抗体反应均受到抑制。因此，靶细胞是Ly-1+ T细胞，可能是辅助细胞。到目前为止测试的所有小鼠品系都能够产生该因子，并且在CBA或B10小鼠中进行测试时，似乎不存在遗传限制，例如，非同种基因的抑制因子与同种基因的因子一样具有抑制作用。将抑制因子的特性与抑制细胞提取物的特性进行比较，发现在起源、作用靶点和效应方面存在差异，这表明它们是不同的分子。文中还讨论了抑制途径的异质性。
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