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加利福尼亚州死产和活产分娩的严重产妇发病率。

Severe Maternal Morbidity Among Stillbirth and Live Birth Deliveries in California.

机构信息

Departments of Pediatrics, Obstetrics and Gynecology, and Anesthesiology, Perioperative, and Pain Medicine, Stanford University School of Medicine, Stanford, California.

出版信息

Obstet Gynecol. 2019 Aug;134(2):310-317. doi: 10.1097/AOG.0000000000003370.

Abstract

OBJECTIVE

To assess the prevalence and risk of severe maternal morbidity among delivery hospitalization for stillbirth compared with live birth deliveries.

METHODS

Using data from the Office of Statewide Health Planning and Development in California, we performed a population-based cross-sectional study of 6,459,842 deliveries between 1999 and 2011. We identified severe maternal morbidity using an algorithm comprising diagnoses and procedures developed by the Centers for Disease Control and Prevention and used log-binomial regression models to examine the relative risk (RR) of severe maternal morbidity for stillbirth compared with live birth deliveries, adjusting for maternal demographic, medical, and obstetric characteristics. We also examined severe maternal morbidity prevalence by cause of fetal death among stillbirth deliveries.

RESULTS

The prevalence of severe maternal morbidity for stillbirth and live birth was 578 and 99 cases per 10,000 deliveries, respectively. After adjusting for maternal demographic, medical, and obstetric characteristics, the risk of severe maternal morbidity among stillbirth deliveries was more than fourfold higher (adjusted RR 4.77; 95% CI 4.53-5.02) compared with live birth deliveries. The severe maternal morbidity prevalence was highest among stillbirths caused by hypertensive disorders and placental conditions (24 and 19 cases/100 deliveries, respectively), and lowest among stillbirths caused by fetal malformations or genetic abnormalities (1 case per 100 deliveries).

CONCLUSION

Women who have stillbirths are at substantially higher risk for severe maternal morbidity than women who have live births, regardless of cause of fetal death. The prevalence of severe maternal morbidity varies by cause of fetal death.

摘要

目的

评估死胎分娩与活产分娩相比严重产妇发病率的流行率和风险。

方法

我们使用加利福尼亚州全州卫生规划和发展办公室的数据,对 1999 年至 2011 年期间的 6459842 例分娩进行了一项基于人群的横断面研究。我们使用由疾病控制与预防中心制定的诊断和程序算法来确定严重产妇发病率,并使用对数二项式回归模型来检查死胎与活产分娩相比严重产妇发病率的相对风险(RR),同时调整产妇的人口统计学、医疗和产科特征。我们还根据死胎分娩的胎儿死亡原因检查了严重产妇发病率的流行率。

结果

死胎和活产的严重产妇发病率分别为每 10000 例分娩 578 例和 99 例。在调整了产妇的人口统计学、医疗和产科特征后,死胎分娩发生严重产妇发病率的风险比活产分娩高四倍多(调整 RR 4.77;95%CI 4.53-5.02)。由高血压疾病和胎盘情况引起的死胎的严重产妇发病率最高(分别为每 100 例分娩 24 例和 19 例),而由胎儿畸形或遗传异常引起的死胎的严重产妇发病率最低(每 100 例分娩 1 例)。

结论

无论胎儿死亡的原因如何,死胎产妇发生严重产妇发病率的风险明显高于活产产妇。严重产妇发病率的流行率因胎儿死亡的原因而异。

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