人类鸟嘌呤核苷酸结合蛋白α i1亚基的基因定位于囊性纤维化基因座附近。
The gene for the alpha i1 subunit of human guanine nucleotide binding protein maps near the cystic fibrosis locus.
作者信息
Bloch D B, Bloch K D, Iannuzzi M, Collins F S, Neer E J, Seidman J G, Morton C C
机构信息
Department of Genetics, Harvard Medical School, Boston, MA 02115.
出版信息
Am J Hum Genet. 1988 Jun;42(6):884-8.
The gene for the alpha i1 subunit of human guanine nucleotide binding (G) protein was mapped by in situ hybridization to chromosome 7 at band q21. The regional chromosomal location of the human alpha i1 gene was confirmed using human/mouse somatic-cell hybrid lines containing portions of human chromosome 7. Because the alpha i1 gene mapped near the cystic fibrosis locus and because an abnormal G protein might be expected to contribute to the pathophysiology of this disease, the alpha i1 gene was mapped with respect to the cystic fibrosis locus as defined by the Met oncogene and anonymous DNA marker pJ3.11. The location of the alpha i1 gene proved to be distinct from that of the cystic fibrosis locus.
通过原位杂交技术，将人类鸟嘌呤核苷酸结合（G）蛋白αi1亚基的基因定位到染色体7的q21带。利用含有部分人类染色体7的人/鼠体细胞杂交系，证实了人类αi1基因在染色体上的区域定位。由于αi1基因定位于囊性纤维化基因座附近，并且预计异常的G蛋白可能与该疾病的病理生理学有关，因此根据Met癌基因和匿名DNA标记pJ3.11所定义的囊性纤维化基因座，对αi1基因进行了定位。结果证明，αi1基因的位置与囊性纤维化基因座不同。
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