研究来自不同来源的耐甲氧西林菌株黏附犬和人角质形成细胞的能力。
Investigating the ability of methicillin-resistant isolates from different sources to adhere to canine and human corneocytes.
作者信息
Phumthanakorn Nathita, Prapasarakul Nuvee
机构信息
Department of Microbiology, Faculty of Veterinary Science, Chulalongkorn University, Henri-Dunant Road, Pathumwan, Bangkok 10330, Thailand (Phumthanakorn, Prapasarakul); Diagnosis and Monitoring of Animal Pathogens Research Unit, Faculty of Veterinary Science, Chulalongkorn University, Henri-Dunant Road, Pathumwan, Bangkok 10330, Thailand (Prapasarakul).
出版信息
Can J Vet Res. 2019 Jul;83(3):231-234.
Assays were done to assess the ability of 5 methicillin-resistant (MRSP) isolates from difference sources to adhere to canine and human corneocytes. Cell wall-associated (CWA) protein gene profiles were examined to look for associations with adherence. Five MRSP strains were studied: 3 with the same CWA protein gene profile (14 genes) and belonging to sequence type (ST) 45 were isolated from a dog, a human, and the environment. The other 2 were an environmental isolate belonging to ST433 that had the lowest number of CWA protein genes (12) and a canine clinical isolate belonging to ST733 that had the greatest number of CWA protein genes (18). The 3 isolates of MRSP ST45, a major clone in Thailand, had the greatest ability to adhere to canine and human corneocytes. Nevertheless, MRSP adherence ability could not be predicted from the profile of genes encoding CWA proteins.
进行了试验以评估5株来自不同来源的耐甲氧西林金黄色葡萄球菌（MRSP）分离株黏附犬和人角质形成细胞的能力。检测细胞壁相关（CWA）蛋白基因图谱，以寻找与黏附的关联。研究了5株MRSP菌株：3株具有相同的CWA蛋白基因图谱（14个基因）且属于序列型（ST）45，分别从一只狗、一名人类和环境中分离得到。另外2株分别是属于ST433的环境分离株，其CWA蛋白基因数量最少（12个），以及属于ST733的犬临床分离株，其CWA蛋白基因数量最多（18个）。MRSP ST45的3株分离株是泰国的主要克隆株，具有最强的黏附犬和人角质形成细胞的能力。然而，无法根据编码CWA蛋白的基因图谱预测MRSP的黏附能力。
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