Ciloglu Emine, Yıldırım Celikdemir Ayse
Department of Ophthalmology, Adana City Training and Research Hospital, Adana, Turkey.
Department of Radiology, Adana City Training and Research Hospital, Adana, Turkey.
Ther Clin Risk Manag. 2019 Jul 4;15:823-830. doi: 10.2147/TCRM.S200658. eCollection 2019.
To determine the early effects of intravitreal anti-VEGF and dexamethasone application on blood flow velocities in patients with retinal vein occlusions.
The ophthalmic (OA) and the central retinal arteries (CRAs) of the affected and unaffected eyes of 21 patients with central retinal vein occlusion (CRVO), and 26 patients with branch retinal vein occlusion (BRVO) were investigated by Color Doppler imaging (CDI). Peak systolic volume (PSV), end diastolic volume (EDV), and average blood velocity (Vmean) of the CRA and OA were measured and resistive indexes (RI) were calculated at pre-injection and the 1st week and 1st month post-injection.
There was no statistically significant difference between the OA values for affected and unaffected eyes in the CRVO group before treatment. The CRA, EDV, and Vmean values were significantly lower in affected eyes. Blood flow velocities of both CRA and OA were not significantly different than in the fellow unaffected eyes in the BRVO group. The differences between PSV, EDV, and Vmean measurements of OA and CRA at different times pre- and post-injection in response to anti-VEGF and dexamethasone treatment in the CRVO group were significant; but there was no difference in RI value. OA blood flow velocity measurements were not statistically different post-injection in the BRVO group; however, the values of PSV and EDV of CRA decreased post-injection.
Intravitreal anti-VEGF and dexamethasone implant may induce retinal arteriolar vasoconstriction in patients with retinal vein occlusion.
确定玻璃体内注射抗血管内皮生长因子（anti-VEGF）和地塞米松对视网膜静脉阻塞患者血流速度的早期影响。
采用彩色多普勒成像（CDI）对21例中央视网膜静脉阻塞（CRVO）患者和26例分支视网膜静脉阻塞（BRVO）患者患眼及对侧未患眼的眼动脉（OA）和视网膜中央动脉（CRA）进行研究。在注射前、注射后第1周和第1个月测量CRA和OA的收缩期峰值流速（PSV）、舒张末期流速（EDV）和平均血流速度（Vmean），并计算阻力指数（RI）。
CRVO组治疗前患眼与对侧未患眼的OA值无统计学差异。患眼的CRA、EDV和Vmean值显著降低。BRVO组患眼CRA和OA的血流速度与对侧未患眼相比无显著差异。CRVO组在抗VEGF和地塞米松治疗后，注射前、后不同时间OA和CRA的PSV、EDV和Vmean测量值差异有统计学意义；但RI值无差异。BRVO组注射后OA血流速度测量值无统计学差异；然而，CRA的PSV和EDV值在注射后降低。
玻璃体内注射抗VEGF和地塞米松植入物可能会导致视网膜静脉阻塞患者的视网膜小动脉血管收缩。
