Matsuoka R, Uno H, Tanaka H, Kerr C S, Nakazawa K, Nadal-Ginard B
Department of Cardiology, Children's Hospital, Boston, Massachusetts.
Am J Med Genet Suppl. 1987;3:433-43. doi: 10.1002/ajmg.1320280548.
At various gestational periods, caffeine was injected intra-arterially or intraperitoneally into pregnant rats. The teratogenic effects of caffeine on the fetal heart were dose dependent and detectable at relatively low concentrations. The most susceptible stage was during septation of the heart. The most common cardiovascular malformation was ventricular septal defect. Extracardiovascular anomalies, such as decreased thymic weight and degeneration of the lens, were found in all fetuses; skeletal malformations were found in some fetuses.
在不同的孕期，将咖啡因经动脉内或腹腔内注射到怀孕大鼠体内。咖啡因对胎儿心脏的致畸作用呈剂量依赖性，在相对较低浓度时即可检测到。最敏感的阶段是心脏分隔期。最常见的心血管畸形是室间隔缺损。在所有胎儿中均发现了心血管外异常，如胸腺重量减轻和晶状体退变；在一些胎儿中发现了骨骼畸形。
