Singh S, Sanyal A K
Acta Anat (Basel). 1976;94(4):490-6. doi: 10.1159/000144581.
Different eye anomalies, e.g. open eye (lid-gap), exophthalmos, cataractous lens, anophthalmia, microphthalmia, corneal opacities and absent lens were induced in rat fetuses by maternal administration of cyclophosphamide on the 12-16th day of gestation. 63-90% of anomalies were found in groups treated between days 13 and 15 of gestation. The 14th day of gestation was found to be the most susceptible, inducing severe eye anomalies in 90% of fetuses treated at this age. Degenerative changes were seen in the lens and retina. The retinal cytoarchitecture was completely disorganised.
在妊娠第12至16天给孕鼠腹腔注射环磷酰胺，可诱导胎鼠出现不同的眼部异常，如睁眼（眼睑裂隙）、眼球突出、晶状体混浊、无眼、小眼、角膜混浊和晶状体缺失。在妊娠第13至15天接受治疗的组中，63%-90%的胎鼠出现异常。发现妊娠第14天最易受影响，在此年龄接受治疗的胎鼠中有90%出现严重的眼部异常。晶状体和视网膜出现退行性变化。视网膜细胞结构完全紊乱。
