Bisschoff Chanté, Coulon Jasmine, Isaacs Ziva, van der Linde Lavinia, Wilson Linley, van Zyl Riana, Joubert Gina
Department of Paediatrics and Child Health, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa.
Department of Biostatistics, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa.
South Afr J HIV Med. 2019 Jun 27;20(1):951. doi: 10.4102/sajhivmed.v20i1.951. eCollection 2019.
Birth polymerase chain reaction (PCR) testing improves early detection of HIV and allows for early treatment initiation. National guidelines exist, but it is unknown whether these are being implemented correctly.
To determine whether HIV-exposed infants at the Mangaung University Community Partnership Programme Community Health Centre (MUCPP CHC) received PCR tests at birth, if HIV-positive infants were initiated on treatment, if follow-up dates were scheduled and the percentage of mothers or caregivers who returned to collect the results.
The study was a retrospective descriptive file audit (1304 files) of births from 01 January to 31 December 2016 at MUCPP CHC. The study sample was 428 infants born to HIV-positive mothers. The birth register was used to collect the infants' HIV PCR test barcodes. The birth and 10-week PCR results were retrieved from an electronic database at the Virology Department, University of the Free State.
In total, 375 infants received a birth PCR test (87.6%) of which 4 (1.1%) tested HIV positive and 327 (87.2%) negative. Follow-up tests were not scheduled. However, 145 (44.3%) HIV-negative infants returned for a 10-week test. Irrespective of the PCR birth result, 157 (36.7%) infants were brought for a 10-week follow-up test at which time 3 (1.9%) tested positive and 151 (96.2%) negative.
The majority of HIV-exposed infants received a PCR test at birth; however, the clinic is below the national target (90%) for HIV testing. A record-keeping system of infants' visits does not exist at MUCPP CHC, making it impossible to determine whether HIV-positive infants were started on antiretroviral treatment.
出生时进行聚合酶链反应(PCR)检测可改善HIV的早期检测,并能实现早期治疗。国家有相关指南,但尚不清楚这些指南是否得到正确实施。
确定在曼加昂大学社区合作项目社区卫生中心(MUCPP CHC),暴露于HIV的婴儿出生时是否接受了PCR检测、HIV阳性婴儿是否开始接受治疗、是否安排了随访日期,以及返回领取检测结果的母亲或照料者的比例。
该研究是对MUCPP CHC在2016年1月1日至12月31日期间出生的婴儿的病历进行回顾性描述性档案审核(共1304份病历)。研究样本为428名HIV阳性母亲所生的婴儿。通过出生登记册收集婴儿的HIV PCR检测条形码。出生时和10周时的PCR检测结果从自由州大学病毒学系的电子数据库中获取。
共有375名婴儿接受了出生时的PCR检测(87.6%),其中4名(1.1%)检测为HIV阳性,327名(87.2%)为阴性。未安排随访检测。然而,145名(44.3%)HIV阴性婴儿返回进行10周检测。无论出生时PCR检测结果如何,157名(36.7%)婴儿接受了10周的随访检测,其中3名(1.9%)检测为阳性,151名(96.2%)为阴性。
大多数暴露于HIV的婴儿在出生时接受了PCR检测;然而,该诊所的HIV检测率低于国家目标(90%)。MUCPP CHC没有婴儿就诊记录系统,因此无法确定HIV阳性婴儿是否开始接受抗逆转录病毒治疗。