State Key Laboratory of Phytochemistry and Plant Resources in West China, CAS Center for Excellence in Molecular Plant Sciences , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650204 , People's Republic of China.
Key Laboratory of Standardization of Chinese Herbal Medicine, College of Pharmacy , Chengdu University of Traditional Chinese Medicine , Chengdu 611137 , People's Republic of China.
J Nat Prod. 2019 Jul 26;82(7):1813-1819. doi: 10.1021/acs.jnatprod.9b00022. Epub 2019 Jul 16.
Eight new sulfur-bridged pyranonaphthoquinone (PNQ) dimers, naquihexcins C-J (-), a new PNQ monomer, naquihexcin K (), and three known analogues (, , and ) were isolated from sp. KIB3133. The new structures were elucidated by interpretation of spectroscopic data. Dimer was synthesized via a cascade S2 reactions between two monomers and sodium sulfide, an approach motivated by the proposed biosynthetic pathway of dimeric pyranonaphthoquinones. Naquihexcin E () exhibited moderate HIV-1 inhibitory activity. Naquihexcins C (), E (), and I () showed inhibitory effects against two tumor cell lines (HL-60 and MCF-7) with IC values ranging from 1.4 to 16.1 μM.
从 sp. KIB3133 中分离得到了 8 个新的硫桥吡喃并萘醌（PNQ）二聚体（naquihexcins C-J (-)）、一个新的 PNQ 单体（naquihexcin K ()）和 3 个已知类似物（,, 和 ）。通过对光谱数据的解释，确定了这些新结构。通过两个单体与硫化钠之间的级联 S2 反应合成了二聚体 ，这种方法受到二聚吡喃并萘醌生物合成途径的启发。Naquihexcin E () 表现出中等的 HIV-1 抑制活性。Naquihexcins C (), E (), 和 I () 对两种肿瘤细胞系（HL-60 和 MCF-7）表现出抑制作用，IC 值范围为 1.4 至 16.1 μM。
