一种来自链霉菌属的新型安莎霉素——萘霉素K
A novel ansamycin, naphthomycin K from Streptomyces sp.
作者信息
Lu Chunhua, Shen Yuemao
机构信息
Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, Xiamen Engineering Research Center of Marine Microbial Drug Discovery, School of Life Science, Xiamen University, Fujian, PR China.
出版信息
J Antibiot (Tokyo). 2007 Oct;60(10):649-53. doi: 10.1038/ja.2007.84.
One novel ansamycin, namely naphthomycin K, together with two known naphthomycins A and E, were isolated from the commensal strain Streptomyces sp. CS of the medicinal plant Maytenus hookeri. Their structures were elucidated by the analysis of NMR and MS data. Naphthomycin K showed evident cytotoxicity against P388 and A-549 cell lines, but no inhibitory activities against Staphylococcus aureus and Mycobacterium tuberculosis.
从药用植物云南美登木的共生菌株链霉菌属CS中分离出一种新型安莎霉素，即萘霉素K，以及两种已知的萘霉素A和E。通过核磁共振（NMR）和质谱（MS）数据分析阐明了它们的结构。萘霉素K对P388和A-549细胞系表现出明显的细胞毒性，但对金黄色葡萄球菌和结核分枝杆菌没有抑制活性。
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