Yu Zhiyin, Jiang Hao, Wang Li, Yang Feng-Xian, Huang Jian-Ping, Liu Chongxi, Guo Xiaowei, Xiang Wensheng, Huang Sheng-Xiong
Heilongjiang Provincial Key Laboratory of Agricultural Microbiology, Northeast Agricultural University, Harbin, China.
State Key Laboratory of Phytochemistry and Plant Resources in West China, CAS Center for Excellence in Molecular Plant Sciences, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China.
Front Chem. 2020 Feb 18;8:95. doi: 10.3389/fchem.2020.00095. eCollection 2020.
Six new pimprinine alkaloids (-), including four dimers, dipimprinines A-D (-), and two monomers, (±)-Pimprinol D (), and pimprinone A (), along with six known congeners (-), were isolated from a soil-derived actinomycete sp. NEAU-C99. Structures of the new compounds were elucidated by extensive spectroscopic analyses, single-crystal X-ray diffractions, and ECD calculations. Dipimprinines A-D (-) showed weak cytotoxic activities against five tumor cell lines, including HL-60, SMMC-7721, A-549, MCF-7, and SW-480, with IC values ranging from 12.7 to 30.7 μM.
从一株土壤来源的放线菌新种NEAU-C99中分离出6个新的匹普林宁生物碱（-），包括4个二聚体，双匹普林宁A-D（-），以及2个单体，（±）-匹普林醇D（）和匹普林酮A（），同时还分离出6个已知的同系物（-）。通过广泛的光谱分析、单晶X射线衍射和电子圆二色（ECD）计算确定了新化合物的结构。双匹普林宁A-D（-）对包括HL-60、SMMC-7721、A-549、MCF-7和SW-480在内的5种肿瘤细胞系显示出较弱的细胞毒性活性，IC值范围为12.7至30.7μM。
