Eye Center, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Chronic Disease Research Institute, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, China.
Sleep. 2019 Oct 21;42(11). doi: 10.1093/sleep/zsz160.
To investigate the relationship between dry eye and sleep quality in a large community-based Chinese population.
A total of 3,070 participants aged 18-80 were recruited from a community-based study in Hangzhou, China during 2016-2017. Sleep quality was evaluated using the Chinese version of the Pittsburgh Sleep Quality Index (CPSQI), and dry eye was evaluated using the Ocular Surface Disease Index (OSDI) questionnaire. Multivariable linear regression and logistic regression models were used to investigate the associations, adjusting for age, smoking, drinking, season, and other potential confounders.
Overall, CPSQI score and sleep dysfunction were significantly associated with mild, moderate, and severe dry eye (ORs for CPSQI score: 1.07, 1.13, 1.14, all p < 0.001; for sleep dysfunction: 1.31, 1.73, 1.66, all p < 0.05). Furthermore, worse OSDI score was presented in participants with worse CPSQI score or sleep dysfunction (CPSQI score > 7) (β: 0.13, 0.54; all p < 0.001). In addition, six of the seven components of CPSQI showed significant associations with dry eye (all p < 0.001), except for the component of sleep medication use. Moreover, we observed significant associations of dry eye in all three subscales of OSDI with CPSQI score and sleep dysfunction.
Our large, community-based study showed a strong association between poor sleep quality and an increased severity of dry eye, suggesting that preventing either one of the discomforts might alleviate the other.
在中国一个大型社区人群中，调查干眼与睡眠质量之间的关系。
2016 年至 2017 年期间，在中国杭州的一个社区基础研究中招募了 3070 名年龄在 18 至 80 岁的参与者。使用匹兹堡睡眠质量指数（CPSQI）的中文版本评估睡眠质量，使用眼表疾病指数（OSDI）问卷评估干眼。使用多变量线性回归和逻辑回归模型进行关联分析，调整年龄、吸烟、饮酒、季节和其他潜在混杂因素。
总体而言，CPSQI 评分和睡眠功能障碍与轻度、中度和重度干眼显著相关（CPSQI 评分的 OR：1.07、1.13、1.14，均 p<0.001；睡眠功能障碍的 OR：1.31、1.73、1.66，均 p<0.05）。此外，在 CPSQI 评分较高（>7）或睡眠功能障碍的参与者中，OSDI 评分更差（CPSQI 评分：0.13、0.54；均 p<0.001）。此外，CPSQI 的七个组成部分中有六个与干眼显著相关（均 p<0.001），除了睡眠药物使用组成部分。此外，我们观察到 OSDI 的三个子量表中的干眼与 CPSQI 评分和睡眠功能障碍均有显著关联。
我们的大型社区研究表明，睡眠质量差与干眼严重程度增加之间存在很强的关联，这表明预防其中任何一种不适可能会减轻另一种不适。
