Rippe Marlène, Cosenza Vanina, Auzély-Velty Rachel
Grenoble Alpes University, Centre de Recherches sur les Macromolécules Végétales (CERMAV)-CNRS, 601, rue de la Chimie, BP 53, CEDEX 9, 38041 Grenoble, France.
Pharmaceutics. 2019 Jul 15;11(7):338. doi: 10.3390/pharmaceutics11070338.
The rapid advancement in medicine requires the search for new drugs, but also for new carrier systems for more efficient and targeted delivery of the bioactive molecules. Among the latter, polymeric nanocarriers have an increasingly growing potential for clinical applications due to their unique physical and chemical characteristics. In this regard, nanosystems based on hyaluronic acid (HA), a polysaccharide which is ubiquitous in the body, have attracted particular interest because of the biocompatibility, biodegradability and nonimmunogenic property provided by HA. Furthermore, the fact that hyaluronic acid can be recognized by cell surface receptors in tumor cells, makes it an ideal candidate for the targeted delivery of anticancer drugs. In this review, we compile a comprehensive overview of the different types of soft nanocarriers based on HA conjugated or complexed with another polymer: micelles, nanoparticles, nanogels and polymersomes. Emphasis is made on the properties of the polymers used as well as the synthetic approaches for obtaining the different HA-polymer systems. Fabrication, characterization and potential biomedical applications of the nanocarriers will also be described.
医学的快速发展不仅需要寻找新药物，还需要寻找新的载体系统，以便更有效地、有针对性地递送生物活性分子。在后者中，聚合物纳米载体由于其独特的物理和化学特性，在临床应用中具有越来越大的潜力。在这方面，基于透明质酸（HA）的纳米系统引起了特别的关注，HA是一种在体内普遍存在的多糖，因其具有生物相容性、可生物降解性和非免疫原性。此外，透明质酸能够被肿瘤细胞表面受体识别，这使其成为抗癌药物靶向递送的理想候选物。在这篇综述中，我们全面概述了基于与另一种聚合物共轭或复合的HA的不同类型的软纳米载体：胶束、纳米颗粒、纳米凝胶和聚合物囊泡。重点介绍了所用聚合物的性质以及获得不同HA-聚合物系统的合成方法。还将描述纳米载体的制备、表征和潜在的生物医学应用。
