Jung Minji, Sung In Young, Ko Eun Jae
Department of Rehabilitation Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Ann Rehabil Med. 2019 Jun;43(3):347-351. doi: 10.5535/arm.2019.43.3.347. Epub 2019 Jun 28.
Joint contracture in chronic graft-versus-host disease (cGVHD) is refractory to treatment, and tends to deteriorate gradually over time. There is scant clinical research focusing on timing and intensity of rehabilitation on joint contractures in children with sclerodermoid cGVHD after hematopoietic stem cell transplantation. We retrospectively reviewed rehabilitative therapeutic effects in 6 children with sclerodermoid cGVHD, whose clinical records documented their condition, before and after rehabilitation therapies. Three children who started treatment within a mean of 2 months after the onset of joint symptoms, and who underwent home-based exercise twice daily for 30 minutes showed more prominent improvement in range of motion compared with the other 3 children, who started rehabilitation therapy later than 6 months after onset of joint symptoms, without regular home-based exercise.
慢性移植物抗宿主病（cGVHD）中的关节挛缩难治，且往往会随时间逐渐恶化。目前针对造血干细胞移植后硬皮病样cGVHD患儿关节挛缩康复治疗的时机和强度的临床研究很少。我们回顾性分析了6例硬皮病样cGVHD患儿的康复治疗效果，这些患儿的临床记录记录了康复治疗前后的病情。3例在关节症状出现后平均2个月内开始治疗且每天在家进行2次、每次30分钟运动锻炼的患儿，与另外3例在关节症状出现6个月后才开始康复治疗且未规律进行家庭锻炼的患儿相比，关节活动度改善更为显著。
