Wewengkang Defny S, Yamazaki Hiroyuki, Takahashi Moe, Togashi Toshiki, Rotinsulu Henki, Sumilat Deiske A, Namikoshi Michio
Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Sendai 981-8558, Japan.
Faculty of Mathematic and Natural Sciences, Sam Ratulangi University, Manado 95115, Indonesia.
J Asian Nat Prod Res. 2020 Aug;22(8):754-761. doi: 10.1080/10286020.2019.1635588. Epub 2019 Jul 16.
A benzyl-α-pyrone metabolite, streptpyrone A (), was obtained together with three known isoflavonoids, daidzein-7--α-l-rhamnoside (), genistein-7--α-l-rhamnoside (), and daidzein (), from the culture broth of an Indonesian actinomycete sp. TPU1401A. The structure of , elucidated based on its spectroscopic data, has been reported as a synthetic compound. However, this is the first report of the isolation of as a metabolite of microbial origin. Strain TPU1401A exhibited the ability to transform the isoflavone aglycones and genistein () into the 7--glycosides and , respectively. Compounds and promoted the growth of strain TPU1401A more effectively than compounds and . These results suggest that strain TPU1401A utilizes isoflavone glycosides to promote growth by transforming isoflavones through microbial glycosidation.
从印度尼西亚放线菌链霉菌属TPU1401A的培养液中获得了一种苄基-α-吡喃酮代谢产物链霉菌吡喃酮A（），以及三种已知的异黄酮类化合物，大豆苷元-7-α-L-鼠李糖苷（）、染料木素-7-α-L-鼠李糖苷（）和大豆苷元（）。基于其光谱数据阐明结构的链霉菌吡喃酮A（）曾被报道为一种合成化合物。然而，这是首次报道从微生物来源分离得到链霉菌吡喃酮A（）。菌株TPU1401A表现出分别将异黄酮苷元大豆苷元和染料木素（）转化为7-糖苷大豆苷元-7-α-L-鼠李糖苷（）和染料木素-7-α-L-鼠李糖苷（）的能力。化合物和比化合物和更有效地促进了菌株TPU1401A的生长。这些结果表明，菌株TPU1401A通过微生物糖基化作用转化异黄酮，利用异黄酮糖苷促进生长。
