Hu Jin-Feng, Wunderlich Dirk, Sattler Isabel, Thiericke Ralf, Grabley Susanne, Feng Xiao-Zhang
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Xian Nong Tan Street, Beijing 100050, P. R. China.
Nat Prod Res. 2003 Dec;17(6):451-8. doi: 10.1080/1478641031000120534.
Chemical screening with extracts of Actinomycetes strains resulted in the detection, isolation and structure elucidation of five new isoflavone glycosides from Streptomyces sp. (GT 51173): 5-O-alpha-L-rhamnopyranosyl genestein (genestein G1, 1), 5-O-alpha-L-rhamnopyranosyl-7-O-[2-O-(methyl)-alpha-L-rhamnopyranosyl] genestein (genestein G2, 2), 7,4'-O-di-[2-O-(methyl)-alpha-L-rhamnopyranosyl] daidzein (daidzein G1, 3), 6-O-methyl-7-O-[2-O-(methyl)-alpha-L-rhamnopyranosyl] daidzein (daidzein G2, 4) and 7-O-[2-O-(methyl)-alpha-L-rhamnopyranosyl] daidzein (daidzein G3, 5). As a striking structural feature, 2-5 bear one or two alpha-L-rhamnopyranosyl sugar moieties with methoxy groups in an axial position at C-2.
用放线菌菌株提取物进行化学筛选，从链霉菌属（GT 51173）中检测、分离并阐明了五种新的异黄酮苷的结构：5-O-α-L-鼠李糖基染料木素（染料木素G1，1）、5-O-α-L-鼠李糖基-7-O-[2-O-（甲基）-α-L-鼠李糖基]染料木素（染料木素G2，2）、7,4'-O-二-[2-O-（甲基）-α-L-鼠李糖基]大豆苷元（大豆苷元G1，3）、6-O-甲基-7-O-[2-O-（甲基）-α-L-鼠李糖基]大豆苷元（大豆苷元G2，4）和7-O-[2-O-（甲基）-α-L-鼠李糖基]大豆苷元（大豆苷元G3，5）。作为一个显著的结构特征，化合物2-5带有一个或两个α-L-鼠李糖基糖部分，其甲氧基在C-2位处于轴向位置。
