a Department of Pharmaceutics, School of Pharmacy, China Medical University , Shenyang , China.
b Department of Sanitary Inspection, School of Public Health, Shenyang Medical College , Shenyang , China.
Expert Opin Drug Deliv. 2019 Aug;16(8):847-867. doi: 10.1080/17425247.2019.1645119. Epub 2019 Jul 25.
: Due to the well-organized structure and barrier function of the skin, it is generally difficult for drugs applied directly on the surface of skin to reach their expected site of action. Accordingly, site-specific drug delivery in the skin has been increasingly explored to facilitate the treatment of skin diseases and reduce the systemic toxicity. : An overview of the generally used sites for drug delivery in the skin is herein presented. Different strategies including particle-based carriers, physical technologies, and chemical approaches are discussed with regards to their potential application in site-specific drug delivery in the skin. : Particle-based carriers are of particular significance for the enhancement of drug delivery in the skin. Although no recommendation can be made regarding which type of carriers can provide better skin penetration, the lipid-based colloidal systems appear to be favored due to their compatibility. In addition, the physical technologies provide unique advantages in delivering hydrophilic macromolecules for the skin immunization. As a new class of permeation enhancers, skin penetrating peptides are gaining more attention in drug delivery to skin cells. For the design of robust site-specific drug delivery systems, the impacts of diseased state and drug properties should not be disregarded.
由于皮肤具有组织有序和屏障功能，直接应用于皮肤表面的药物通常难以到达其预期的作用部位。因此，人们越来越多地探索在皮肤中的特定部位给药，以方便治疗皮肤疾病和降低全身毒性。本文概述了一般用于皮肤给药的部位。讨论了包括基于粒子的载体、物理技术和化学方法在内的不同策略，以及它们在皮肤特定部位药物传递中的潜在应用。基于粒子的载体对于增强药物在皮肤中的传递具有特别重要的意义。尽管无法就哪种类型的载体能提供更好的皮肤穿透性提出建议，但由于其相容性，基于脂质的胶体系统似乎更受欢迎。此外，物理技术在为皮肤免疫提供亲水性大分子方面具有独特的优势。作为一类新型的促渗剂，透皮肽在递送至皮肤细胞的药物中越来越受到关注。为了设计稳健的特定部位药物传递系统，不应忽视疾病状态和药物特性的影响。
