Jindal Anu, Bala Rajni, Singh Amrinder
Chitkara University, Chitkara College of Pharmacy, Rajpura, Punjab, India.
Department of Pharmaceutics, GHG Khalsa College of Pharmacy, Gurusar, Sadhar, Punjab, India.
Arch Dermatol Res. 2025 Apr 12;317(1):706. doi: 10.1007/s00403-025-04239-2.
Microneedles are tiny, minimally invasive needles that are made to create microchannels over a subcutaneous layer of the skin. These micro-injuries encourage the secretion of growth factors and prompt collagen synthesis. The reasons for using microneedling therapy have increased significantly, leading to its widespread adoption in dermatology. This review article discussed recent advances and challenges of microneedle technology for enhanced topical treatment of skin disorders. It discussed the effective and safe use of microneedles for treating different types of skin conditions like acne, scars, alopecia, melasma, skin rejuvenation, and photo-damage. The drug delivery through the skin was enhanced and rare or permanent adverse effects were not mentioned, while temporary redness and post-inflammatory hyperpigmentation were frequently seen. Microneedling seems to be a generally reliable and secure treatment choice for various skin conditions. More extensive and randomized clinical trials were necessary to ensure their safety and efficacy across diverse populations, conditions, and treatment durations. This trial helps to identify optimal dosages, long-term outcomes, and any adverse effects that may not appear in smaller studies. They also enable comparisons with existing therapies, ensuring the technology's generalizability and value. Moreover, such trials are essential for regulatory approval and to determine which microneedle technologies work best for specific uses.
微针是微小的、微创的针头，其制作目的是在皮肤的皮下层创建微通道。这些微损伤会促进生长因子的分泌并促使胶原蛋白合成。使用微针疗法的原因显著增加，这导致其在皮肤科得到广泛应用。这篇综述文章讨论了微针技术在增强皮肤疾病局部治疗方面的最新进展和挑战。它讨论了微针在治疗不同类型皮肤病症（如痤疮、疤痕、脱发、黄褐斑、皮肤年轻化和光损伤）方面的有效和安全应用。通过皮肤的药物递送得到了增强，且未提及罕见或永久性的不良反应，不过临时发红和炎症后色素沉着较为常见。对于各种皮肤病症而言，微针疗法似乎是一种总体上可靠且安全的治疗选择。需要进行更广泛的随机临床试验，以确保其在不同人群、病症和治疗时长下的安全性和有效性。这项试验有助于确定最佳剂量、长期疗效以及在较小规模研究中可能未出现的任何不良反应。它们还能与现有疗法进行比较，确保该技术的通用性和价值。此外，此类试验对于监管批准以及确定哪种微针技术最适用于特定用途至关重要。
