Desmet Eline, Van Gele Mireille, Lambert Jo
a Department of Dermatology , Ghent University Hospital , Ghent , Belgium.
Expert Opin Drug Deliv. 2017 Jan;14(1):109-122. doi: 10.1080/17425247.2016.1206073. Epub 2016 Jul 7.
In the treatment of dermatological disorders, topical drug administration is a mainstay. However, nanoparticle-based carrier systems could improve and expand the current therapeutic range via localized delivery of active ingredients. Areas covered: This review gives a detailed description of lipid- and surfactant-based drug delivery systems which have been explored for topical drug administration. To guide researchers in their choice of delivery system, an informative decision tree is included. Moreover, this review provides a complete overview of the topical or transdermal drug products, currently on the market or under clinical investigation, delivered via the discussed carriers, in the treatment of skin disorders. Expert opinion: Conventional liposomes are still popular in the domain of topical or transdermal drug delivery and dominate the market landscape. However, several other carriers, such as exosomes and niosomes, are being explored which offer distinct advantages over liposomes and should therefore not be disregarded when selecting a proper drug delivery system.
在皮肤病的治疗中，局部给药是主要手段。然而，基于纳米颗粒的载体系统可通过活性成分的局部递送改善并扩大当前的治疗范围。涵盖领域：本综述详细描述了已用于局部给药研究的基于脂质和表面活性剂的药物递送系统。为指导研究人员选择递送系统，文中包含了一个信息丰富的决策树。此外，本综述全面概述了目前市场上或正在进行临床研究的、通过所讨论的载体递送用于治疗皮肤疾病的局部或透皮药物产品。专家观点：传统脂质体在局部或透皮药物递送领域仍然很受欢迎，并主导着市场格局。然而，正在探索其他几种载体，如外泌体和非离子型脂质体，它们相对于脂质体具有明显优势，因此在选择合适的药物递送系统时不应被忽视。
