从皮查瓦拉姆红树林分离出的具有抗菌潜力的链霉菌BDUSMP 02中非核糖体肽合成酶（NRPS）腺苷酸结构域的系统发育分析
Phylogenetic insight of Nonribosomal peptide synthetases (NRPS) Adenylate domain in Antibacterial potential Streptomyces BDUSMP 02 isolated from Pitchavaram Mangrove.
作者信息
Sivalingam Periyasamy, Muthuselvam Manickam, Pote John, Prabakar Kandasamy
机构信息
Department F.A. Forel for Environmental and Aquatic Sciences and Institute of Environmental Sciences, School of Earth and Environmental Sciences, Faculty of Science, University of Geneva, Uni Carl Vogt, 66 Boulevard Carl-Vogt, CH-1211 Geneva 4, Switzerland.
Department of Biotechnology and Genetic Engineering, Bharathidasan University, Tiruchirappalli-620024, Tamil Nadu, India.
出版信息
Bioinformation. 2019 Jun 15;15(6):412-418. doi: 10.6026/97320630015412. eCollection 2019.
Identification of gene clusters in Streptomyces holds promise for the discovery of regulatory pathways linked to bioactive metabolites. We isolated a broad-spectrum antibacterial potential Streptomyces sp BDUSMP 02 from mangrove sediment. We further found a distinct of phylogeny pattern for NRPS A-domain in the Streptomyces sp BDUSMP 02. The result suggests that Streptomyces sp BDUSMP 02 has the potential to produce a new type of antibacterial compounds belonging to NRPS type.
在链霉菌中鉴定基因簇有望发现与生物活性代谢物相关的调控途径。我们从红树林沉积物中分离出一株具有广谱抗菌潜力的链霉菌BDUSMP 02。我们进一步发现链霉菌BDUSMP 02中NRPS A结构域有独特的系统发育模式。结果表明，链霉菌BDUSMP 02有潜力产生一种新型的属于NRPS类型的抗菌化合物。
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