Thandayuthapani Deepika, Chinnappa Nivetha, Annavi Arjunan, Manickam Muthusevam
Department of Biotechnology, Bharathidasan University, Tiruchirappalli-620020, Tamilnadu, India.
Bioinformation. 2021 Sep 30;17(9):809-813. doi: 10.6026/97320630017809. eCollection 2021.
This study aims to find out the mapping of bioactive compounds by combinational analysis of regulatory machinery pattern study and metabolomics approach. In which we isolated a highly potent from Gulf of Manner, which shows broad-spectrum activity against several pathogens. So the isolate was used for overall metabolic profiling studies on crude extract and phylogeny pattern analysis of NRPS A-domain, which is an important gene clusters and plays vital role in production of bioactive metabolites. The result suggests that has the potential to produce a new type of antibacterial compounds.
本研究旨在通过调控机制模式研究与代谢组学方法的组合分析来找出生物活性化合物的图谱。在此过程中，我们从马纳尔湾分离出一种高效菌株，它对多种病原体具有广谱活性。因此，该分离株被用于对粗提物进行全面的代谢谱研究以及对NRPS A结构域进行系统发育模式分析，NRPS A结构域是一个重要的基因簇，在生物活性代谢物的产生中起着至关重要的作用。结果表明，该菌株有潜力产生一种新型抗菌化合物。
