Nonaka Taro, Takahashi Makiko, Nonaka Chika, Enomoto Takayuki, Takakuwa Koichi
Department of Obstetrics and Gynecology Niigata University Medical and Dental Hospital Niigata Japan.
Center for Perinatal, Maternal and Neonatal Medicine Niigata University Medical and Dental Hospital Niigata Japan.
Reprod Med Biol. 2019 Jun 24;18(3):296-301. doi: 10.1002/rmb2.12281. eCollection 2019 Jul.
Inversion of chromosome 9 (inv[9]) is considered to be a normal variant, and the inv(9) in patients or husbands with recurrent pregnancy loss (RPL) is believed to be harmless. However, there are few reports concerning the outcomes of pregnancy in patients with RPL when the patient or their partner has inv(9). In this study, we analyzed the outcomes of pregnancy in this patient population.
Chromosomal karyotyping was performed for 2006 couples with RPL (two or more consecutive early pregnancy losses including non-visualized cases) with their informed consent. The frequency of various chromosomal abnormalities in the patient population was then analyzed, and the outcomes of pregnancy in patients with inv(9) were investigated.
The frequency of inv(9) in the overall population was 2.6% (52/2006). Thus far, 32 patients have conceived repetitively, resulting in live births in 23 cases and early pregnancy losses in nine cases. Four of the nine cases obtained a good outcome in the subsequent pregnancy. Thus, a successful outcome was obtained in 27 of the 32 (84.4%) cases.
This study suggests that inv(9) has no adverse influence on subsequent pregnancy.
9号染色体倒位（inv[9]）被认为是一种正常变异，且认为复发性流产（RPL）患者或其丈夫的inv(9)无害。然而，关于RPL患者自身或其伴侣存在inv(9)时的妊娠结局的报道较少。在本研究中，我们分析了这一患者群体的妊娠结局。
在2006对有复发性流产（两次或更多次连续早期妊娠丢失，包括未见到胎心搏动的情况）的夫妇知情同意的情况下，进行染色体核型分析。然后分析该患者群体中各种染色体异常的频率，并研究存在inv(9)的患者的妊娠结局。
总体人群中inv(9)的频率为2.6%（52/2006）。到目前为止，32例患者再次怀孕，23例分娩活婴，9例早期妊娠丢失。9例中的4例在随后的妊娠中获得了良好结局。因此，32例中的27例（84.4%）获得了成功结局。
本研究表明，inv(9)对随后的妊娠没有不良影响。
