Yamagami Akiko, Wakakura Masato, Inoue Kenji, Ishikawa Hitoshi, Takahashi Toshiyuki, Tanaka Keiko
Inouye Eye Hospital, Tokyo, Japan.
Department of Ophthalmology, Kitasato University Hospital, Sagamihara, Japan.
Neuroophthalmology. 2018 Oct 9;43(2):71-80. doi: 10.1080/01658107.2018.1520905. eCollection 2019 Apr.
To investigate the clinical characteristics and the effectiveness of maintenance therapy of anti-AQP4 antibody positive optic neuritis in Japanese patients, medical records from 69 patients (103 eyes) were retrospective reviewed. The status of relapse in patients who received maintenance therapy following acute therapy was compared with that before maintenance therapy in patients who started maintenance therapy ≥6 months after acute therapy. In Japan, anti-AQP4 antibody positive optic neuritis was characterized by older onset age and poor visual outcome. The yearly rate and total number of relapses were lower when maintenance therapy was followed immediately after acute therapy.
为了调查日本抗水通道蛋白4（AQP4）抗体阳性视神经炎患者的临床特征及维持治疗的有效性，对69例患者（103只眼）的病历进行了回顾性研究。对急性治疗后接受维持治疗的患者的复发情况，与急性治疗后≥6个月开始维持治疗的患者维持治疗前的复发情况进行了比较。在日本，抗AQP4抗体阳性视神经炎的特点是发病年龄较大且视力预后较差。急性治疗后立即进行维持治疗时，年复发率和复发总数较低。
