氟的阴暗面。
The Dark Side of Fluorine.
作者信息
Pan Yue
机构信息
Global Discovery Chemistry, Novartis Institutes for BioMedical Research, 22 Windsor Street, Cambridge, Massachusetts 02139, United States.
出版信息
ACS Med Chem Lett. 2019 Jun 20;10(7):1016-1019. doi: 10.1021/acsmedchemlett.9b00235. eCollection 2019 Jul 11.
Abstract
Despite the perceived stability of the C-F bond, chemical instability and drug-metabolizing enzymes can lead to its cleavage. The resulting release of fluoride and formation of certain metabolites may cause safety issues and warrant the medicinal chemists' attention.
摘要
尽管C-F键看似稳定，但化学不稳定性和药物代谢酶可导致其断裂。由此产生的氟化物释放和某些代谢物的形成可能会引发安全问题，值得药物化学家关注。
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