含有淋病奈瑟菌主要外膜蛋白的脂质体和免疫刺激复合物的免疫原性：蛋白质含量和脂质体双层组成的影响
Immunogenicity of liposomes and iscoms containing the major outer membrane protein of Neisseria gonorrhoeae: influence of protein content and liposomal bilayer composition.
作者信息
Kersten G F, van de Put A M, Teerlink T, Beuvery E C, Crommelin D J
机构信息
Department of Inactivated Viral Vaccines, National Institute for Public Health and Environmental Protection, Bilthoven, The Netherlands.
出版信息
Infect Immun. 1988 Jun;56(6):1661-4. doi: 10.1128/iai.56.6.1661-1664.1988.
Abstract
The influences of Neisseria gonorrhoeae protein IB content and bilayer composition of liposomes and protein content of iscoms on immunogenicity were investigated. Changes in the protein content of liposomes did not influence the immunoglobulin G response, whereas the response was lowered when the amount of protein in iscoms was increased. Bilayer composition only influenced the primary immunoglobulin G response; immunological memory was not affected.
摘要
研究了淋病奈瑟菌蛋白IB含量、脂质体双层组成以及免疫刺激复合物（iscoms）蛋白含量对免疫原性的影响。脂质体蛋白含量的变化不影响免疫球蛋白G反应，而当iscoms中蛋白量增加时反应降低。双层组成仅影响初次免疫球蛋白G反应；免疫记忆不受影响。
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