Yokota Nozomi, Ae Ryusuke, Amenomori Masaki, Kitagawa Koji, Nakamura Takuya, Yokota Tetsuro, Masato Kato, Sasahara Teppei, Matsubara Yuri, Kosami Koki, Nakamura Yoshikazu
Shiga Center for Family Medicine Yuge Medical Clinic Shiga Japan.
Division of Public Health Center for Community Medicine Jichi Medical University Tochigi Japan.
J Gen Fam Med. 2019 Apr 10;20(4):139-145. doi: 10.1002/jgf2.245. eCollection 2019 Jul.
Few studies have reported the influence of clinical background factors on the outcome of eradication therapy in primary care practice. We aimed to determine which clinical background factors influence the outcome of eradication therapy in a primary care setting.
This was a retrospective study of patients who received eradication therapy at Higashiohmi City Gamo Medical Center, Shiga, Japan, from January 2012 to December 2015. We investigated clinical background factors associated with success, failure, and self-interruption of eradication therapy: patients' age, gender, first- or second-line treatment, reasons for receiving gastroenterological endoscopic examination, method of drug administration, and attending physicians' age and their specialties.
There were 369 patients (208 females, 161 male), with a mean age of 59 years (range 30-88 years). The middle-aged group (50-69 years) was associated with successful eradication therapy compared with the young group (30-49 years). The elderly group (>70 years) was associated with eradication therapy failure compared with the middle-aged group. The young group was associated with self-interruption of eradication therapy. There was a marginally significant association between male patients and self-interruption. Older attending physicians (>50 years) were also associated with failure compared with younger physicians. There was no difference in outcome of eradication therapy between generalists and gastroenterology specialists.
We have identified clinical factors associated with success, failure, and self-interruption of eradication therapy in a primary care setting.
很少有研究报道临床背景因素对基层医疗实践中根除治疗结果的影响。我们旨在确定哪些临床背景因素会影响基层医疗环境中根除治疗的结果。
这是一项对2012年1月至2015年12月在日本滋贺县东近江市加茂医疗中心接受根除治疗的患者进行的回顾性研究。我们调查了与根除治疗成功、失败和自我中断相关的临床背景因素：患者的年龄、性别、一线或二线治疗、接受胃肠内镜检查的原因、给药方法以及主治医生的年龄和专业。
共有369例患者（女性208例，男性161例），平均年龄59岁（范围30 - 88岁）。与年轻组（30 - 49岁）相比，中年组（50 - 69岁）与根除治疗成功相关。与中年组相比，老年组（>70岁）与根除治疗失败相关。年轻组与根除治疗的自我中断相关。男性患者与自我中断之间存在微弱的显著关联。与年轻医生相比，年龄较大的主治医生（>50岁）也与治疗失败相关。全科医生和胃肠病专科医生在根除治疗结果上没有差异。
我们已经确定了基层医疗环境中与根除治疗成功、失败和自我中断相关的临床因素。
