Scotti Gianmario, Nilsson Sofia M E, Matilainen Ville-Pekka, Haapala Markus, Boije Af Gennäs Gustav, Yli-Kauhaluoma Jari, Salminen Antti, Kotiaho Tapio
Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, P.O. Box 56 (Viikinkaari 5 E), FI-00014, University of Helsinki, Finland.
Laser Processing Research Group, Lappeenranta University of Technology, Tuotantokatu 2, FI-53850, Lappeenranta, Finland.
Heliyon. 2019 Jul 2;5(7):e02002. doi: 10.1016/j.heliyon.2019.e02002. eCollection 2019 Jul.
A simple flow chemistry microreactor with an electrospray ionization tip for real time mass spectrometric reaction monitoring is introduced. The microreactor was fabricated by a laser-based additive manufacturing technique from acid-resistant stainless steel 316L. The functionality of the microreactor was investigated by using an inverse electron demand Diels-Alder and subsequent retro Diels-Alder reaction for testing. Challenges and problems encountered are discussed and improvements proposed. Adsorption of reagents to the rough stainless steel channel walls, short length of the reaction channel, and making a proper ESI tip present challenges, but the microreactor is potentially useful as a disposable device.
介绍了一种带有电喷雾电离尖端的简单流动化学微反应器，用于实时质谱反应监测。该微反应器由耐酸不锈钢316L通过基于激光的增材制造技术制成。通过使用逆电子需求狄尔斯-阿尔德反应及随后的逆狄尔斯-阿尔德反应进行测试，研究了微反应器的功能。讨论了遇到的挑战和问题，并提出了改进建议。试剂吸附到粗糙的不锈钢通道壁上、反应通道长度较短以及制作合适的电喷雾电离尖端都带来了挑战，但该微反应器作为一次性装置具有潜在用途。
