Ponticelli D, D'Ambrosio A, Cancellieri M, Agozzino E
Department of Experimental Medicine, University of Campania "L.Vanvitelli", Naples, Italy.
Centre for Primary Care and Public Health, Queen Mary University of London, UK.
J Prev Med Hyg. 2019 Jun 28;60(2):E147-E157. doi: 10.15167/2421-4248/jpmh2019.60.2.1018. eCollection 2019 Jun.
Invasive meningococcal disease (IMD) is a severe disease caused by various Neisseria meningitidis serogroups that represents a serious public health problem worldwide. In Italy, serogroups B and C are the major causes of IMD. On 14 January 2013, the European Medicines Agency authorized the use of the first vaccine available to protect against meningococcal serogroup B (4CMenB). The aim of this study was to assess the IMD epidemiology knowledge and 4CMenB vaccine attitudes of healthcare workers (HCWs) with regard to recommending this vaccine for use, vaccine practices and infectious disease control in the Campania region in Italy. A cross-sectional study was conducted among 293 HCWs (49.5% physicians and 46.4% nurses)interviewed using a self-administered questionnaire. The majority of the HCWs had sufficient knowledge about the disease incidence and lethality, but they were less informed about the higher risk age categories and the serogroups most frequently involved. Additionally, their knowledge about the vaccine was poor with regard to the targeted categories and side effects. Approximately30.0% of the HCWs reported incidences of fever and pain and swelling at the injection site. Moreover,32.8% of the HCWs knew that the risk of developing adverse reactions increases when the 4CMenB vaccine is co-administered with other vaccines. Overall, all of the HCWs were convinced that vaccinations are an important instrument for preventing infectious diseases, and they were aware of their central role in promoting the 4CmenB vaccination and their need to be better informed.
侵袭性脑膜炎球菌病（IMD）是一种由多种脑膜炎奈瑟菌血清群引起的严重疾病，在全球范围内都是一个严重的公共卫生问题。在意大利，B 群和 C 群血清型是 IMD 的主要病因。2013 年 1 月 14 日，欧洲药品管理局批准使用第一种可预防 B 群脑膜炎球菌（4CMenB）的疫苗。本研究的目的是评估意大利坎帕尼亚地区医护人员（HCWs）在推荐使用该疫苗、疫苗接种实践和传染病控制方面对 IMD 流行病学的了解以及对 4CMenB 疫苗的态度。采用自填式问卷对 293 名医护人员（49.5%为医生，46.4%为护士）进行了横断面研究。大多数医护人员对该疾病的发病率和致死率有足够的了解，但他们对高风险年龄类别以及最常涉及的血清群了解较少。此外，他们对疫苗在目标人群和副作用方面的了解也很匮乏。约 30.0%的医护人员报告有发热、注射部位疼痛和肿胀的情况。此外，32.8%的医护人员知道 4CMenB 疫苗与其他疫苗同时接种时发生不良反应的风险会增加。总体而言，所有医护人员都坚信疫苗接种是预防传染病的重要手段，他们意识到自己在推广 4CMenB 疫苗接种方面的核心作用以及需要更好地了解相关信息。
