School of Applied Psychology, Menzies Health Institute Queensland, Griffith University, Mount Gravatt, Queensland, 4122, Australia.
School of Medicine, University of Queensland, St Lucia, Queensland, Australia.
J Cancer Surviv. 2019 Oct;13(5):653-662. doi: 10.1007/s11764-019-00784-8. Epub 2019 Jul 17.
The impact of brain tumour on subjective cognitive function (SCF) has received little attention despite the implications of these perceptions for quality of life. SCF consists of two related yet distinct components, perceived cognitive impairment (PCI) and perceived cognitive abilities (PCA). This study compared the SCF of adult brain tumour survivors and healthy controls and examined demographic, illness-related, and psychological factors associated with SCF.
Sixty-five adult survivors with primary brain tumour (age, 22-75 years), and 65 age- and sex-matched controls were recruited. Participants with brain tumour completed the Brief Test of Adult Cognition by Telephone, Functional Assessment of Cancer Therapy-Cognitive Function (FACT-Cog), ratings of physical symptoms, Depression Scale of the Depression Anxiety Stress Scales-21 (DASS-Depression), and Generalized Anxiety Disorder-7 (GAD-7) scale. Controls completed the FACT-Cog, DASS-Depression, and GAD-7.
Adult brain tumour survivors reported significantly greater PCI and lower PCA than controls, after accounting for anxiety. Higher PCI was significantly related to fatigue, pain, treatment-related side-effects, anxiety, and depression. Lower PCA was significantly associated with fatigue, pain, poorer objective cognitive function, lower education, anxiety, and depression. Anxiety uniquely accounted for 9-14% of variance in SCF.
Adult brain tumour survivors were found to experience poorer SCF than healthy controls after accounting for anxiety. SCF was related to multiple factors after brain tumour; however, an independent association with anxiety was identified.
These findings highlight the potential value of psychological interventions targeting anxiety and cognitive effects to improve quality of survivorship after brain tumour.
尽管这些认知感知对生活质量有影响，但脑瘤对主观认知功能（SCF）的影响却很少受到关注。SCF 由两个相关但又不同的组成部分组成，即感知认知障碍（PCI）和感知认知能力（PCA）。本研究比较了成年脑瘤幸存者和健康对照者的 SCF，并探讨了与 SCF 相关的人口统计学、疾病相关和心理因素。
招募了 65 名患有原发性脑瘤的成年幸存者（年龄 22-75 岁）和 65 名年龄和性别匹配的对照者。脑瘤患者完成了电话简易成人认知测试、癌症治疗功能评估认知功能（FACT-Cog）、身体症状评分、抑郁焦虑应激量表-21 抑郁量表（DASS-Depression）和广泛性焦虑障碍-7 量表（GAD-7）。对照组完成了 FACT-Cog、DASS-Depression 和 GAD-7。
在考虑到焦虑的情况下，成年脑瘤幸存者报告的 PCI 明显更高，PCA 明显更低。较高的 PCI 与疲劳、疼痛、治疗相关的副作用、焦虑和抑郁显著相关。较低的 PCA 与疲劳、疼痛、较差的客观认知功能、较低的教育程度、焦虑和抑郁显著相关。焦虑可单独解释 SCF 变异的 9-14%。
在考虑到焦虑的情况下，成年脑瘤幸存者的 SCF 明显低于健康对照组。SCF 与脑瘤后的多种因素有关，但与焦虑有独立的关联。
这些发现强调了针对焦虑和认知影响的心理干预的潜在价值，以改善脑瘤后的生存质量。
