通过碳氟键活化实现多氟芳烃与腙的极性反转交叉偶联。
Umpolung cross-coupling of polyfluoroarenes with hydrazones via activation of C-F bonds.
作者信息
Cao Dawei, Pan Pan, Zeng Huiying, Li Chao-Jun
机构信息
The State Key Laboratory of Applied Organic Chemistry, Lanzhou University, 222 Tianshui Road, Lanzhou, 730000, P. R. China.
Department of Chemistry and FQRNT Centre for Green Chemistry and Catalysis, McGill University, 801 Sherbrooke Street West, Montreal, Quebec H3A 0B8, Canada.
出版信息
Chem Commun (Camb). 2019 Aug 14;55(63):9323-9326. doi: 10.1039/c9cc04299g. Epub 2019 Jul 17.
An umpolung strategy for the cross-coupling of polyfluoroarenes with various substituted hydrazones to construct C(sp)-C(sp) bonds is developed. In this strategy, the C-F bond of polyfluoroarenes is cleaved and coupled with moisture- and air-stable hydrazones under mild conditions with good to excellent yields. This method provides a useful tool for synthesizing polyfluorinated pharmaceuticals and functional materials.
开发了一种用于多氟芳烃与各种取代腙交叉偶联以构建C(sp)-C(sp)键的极性反转策略。在该策略中，多氟芳烃的C-F键被裂解，并在温和条件下与对湿气和空气稳定的腙偶联，产率良好至优异。该方法为合成多氟药物和功能材料提供了一种有用的工具。
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