Halfon Neal, Forrest Christopher B., Lerner Richard M., Faustman Elaine M., Tullis Ericka, Son John
Department of Pediatrics, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA
Department of Health Policy and Management, Fielding School of Public Health, UCLA, Los Angeles, CA, USA
A critical mass of research linking early life events, experiences, and exposures with adult health conditions is delineating the developmental origins of many common chronic diseases. This emerging body of life course health development (LCHD) research specifies the complex adaptive processes by which both adversity and opportunity are integrated into developing biobehavioral systems. It is also challenging long-held views about origins and etiology of health and disease. There is a growing momentum among practitioners and policymakers to “connect the dots” between this rapidly expanding evidence base and the related practices and policies that are implemented within the fields of medicine, public health, nursing, mental health, education, urban planning, community development, social welfare, and others. At the same time, there is a strong impetus among LCHD researchers to continue to fill the substantial gaps in our knowledge and to ensure that research findings are appropriately synthesized and translated before being applied in clinical, public health, or public policy contexts. Comprised of 26 chapters that grew out of the 2013 Maternal and Child Health (MCH) Life Course Research Agenda-Setting Meeting that was organized by the MCH Life Course Research Network (LCRN) and funded by Health Resources and Services Administration-Maternal and Child Health Bureau (HRSA-MCHB), this volume assesses what has been learned as the LCHD field has emerged, takes stock of what we know and do not know about how health and disease develop, provides some initial guidance regarding the kinds of interventions and efforts that can be beneficial, and lays the foundation for a research agenda that identifies high-priority areas for basic, clinical, population, and translational investigations in order to strategically target resources and efforts and advance the life course health sciences. In this introductory chapter, we begin by providing a rationale for the publication of this volume, including an historical overview that traces the emergence of the LCHD field and provides evidence of a significant, but as yet incomplete, transformation in how we think about and promote health. We go on to describe the purpose, structure, and content of the volume and examine some of the challenges the evolving field must consider as it adaptively moves forward. Finally, we provide readers with information about each section and chapter in this volume, including the impressive backgrounds of the various experts who contributed substantial amounts of both time and original thinking in their roles as authors.
大量研究将早期生活事件、经历和接触与成人健康状况联系起来,正在勾勒出许多常见慢性病的发育起源。这一新兴的生命历程健康发展(LCHD)研究领域明确了复杂的适应性过程,通过这些过程,逆境和机遇都融入到了生物行为系统的发育中。它也在挑战关于健康与疾病起源和病因的长期观点。从业者和政策制定者越来越有动力在这一迅速扩大的证据基础与医学、公共卫生、护理、心理健康、教育、城市规划、社区发展、社会福利等领域实施的相关实践和政策之间“建立联系”。与此同时,LCHD研究人员有强烈的动力继续填补我们知识中的重大空白,并确保在将研究结果应用于临床、公共卫生或公共政策背景之前,对其进行适当的综合和转化。本书由26章组成,这些章节源自2013年由母婴健康生命历程研究网络(LCRN)组织并由卫生资源与服务管理局-母婴健康局(HRSA-MCHB)资助的母婴健康(MCH)生命历程研究议程设定会议。本书评估了随着LCHD领域的出现我们所学到的知识,盘点了我们对健康与疾病如何发展的已知和未知情况,就可能有益的干预措施和努力提供了一些初步指导,并为一项研究议程奠定了基础,该议程确定了基础、临床、人群和转化研究的高度优先领域,以便战略性地分配资源和努力,推进生命历程健康科学。在这一介绍性章节中,我们首先阐述出版本书的理由,包括历史概述,追溯LCHD领域的出现,并提供证据表明我们对健康的思考和促进方式发生了重大但尚未完成的转变。接着,我们描述本书的目的、结构和内容,并审视这个不断发展的领域在适应性向前发展时必须考虑的一些挑战。最后,我们向读者提供有关本书各部分和各章节的信息,包括各位专家令人印象深刻的背景,他们作为作者投入了大量时间并贡献了原创思想。