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曼氏血吸虫病神经型实验模型中眼部受累情况的特征描述。

Characterisation of ocular involvement in an experimental model of neuroschistosomiasis mansoni.

作者信息

Fidelis Thiago Andre Alves, Brasileiro-Filho Geraldo, Santos Helena Hollanda, Vasconcelos-Santos Daniel Vitor, Parreiras Patricia M, Coelho Paulo Marcos Z, Araujo Neusa, Chaud Marco Vinicius, Lambertucci José Roberto

机构信息

Universidade Federal de Minas Gerais, Faculdade de Medicina, Departamento de Doenças Infectoparasitárias, Belo Horizonte, MG, Brasil.

Universidade de Sorocaba, Laboratório de Biomateriais e Nanotecnologia, Sorocaba, SP, Brasil.

出版信息

Mem Inst Oswaldo Cruz. 2019;114:e190029. doi: 10.1590/0074-02760190029. Epub 2019 Jul 15.

DOI:10.1590/0074-02760190029
PMID:31314860
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6629375/
Abstract

The Global Burden of Disease Study 2010 listed schistosomiasis among the leading 100 causes of death in Brazil, responsible for 3.6% of the estimated total of deaths globally. Eye and adnexa are very rarely affected by schistosomiasis mansoni, with limited documentation of ocular pathology in this setting. This short communication reports ocular histolopathological findings in a murine model of neuroschistosomiasis mansoni. Lesions were found in the bulbar conjunctiva, lacrimal gland, choroid and corneoscleral limbus.

摘要

《2010年全球疾病负担研究》将血吸虫病列为巴西主要的100种死因之一,占全球估计死亡总数的3.6%。曼氏血吸虫病极少累及眼及附属器,关于这种情况下眼部病理学的文献记载有限。本简短通讯报道了曼氏神经血吸虫病小鼠模型中的眼部组织病理学发现。在球结膜、泪腺、脉络膜和角膜巩膜缘发现了病变。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b74b/6629375/467eb5ff5682/1678-8060-mioc-114-e190029-gf2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b74b/6629375/5f3832814153/1678-8060-mioc-114-e190029-gf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b74b/6629375/467eb5ff5682/1678-8060-mioc-114-e190029-gf2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b74b/6629375/5f3832814153/1678-8060-mioc-114-e190029-gf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b74b/6629375/467eb5ff5682/1678-8060-mioc-114-e190029-gf2.jpg

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Schistosoma mansoni granulomas in the skeletal striated muscles in the murine model of neuroschistosomiasis: histological findings.

本文引用的文献

1
Ocular pathological changes in hamsters experimentally infected with Schistosoma mansoni.实验感染曼氏血吸虫的仓鼠眼部病理变化
J Helminthol. 2016 Nov;90(6):773-778. doi: 10.1017/S0022149X1500111X. Epub 2016 Feb 17.
2
Histological and histomorphometric evaluation of the retina of mice infected with Schistosoma mansoni in its hepatosplenic form.曼氏血吸虫肝脾型感染小鼠视网膜的组织学和组织形态计量学评估。
Acta Cir Bras. 2009 Nov-Dec;24(6):502-6. doi: 10.1590/s0102-86502009000600014.
3
[A perfusion technic for recovery of Schistosoma mansoni from experimentally infected guinea pigs].
曼氏血吸虫病神经型小鼠模型骨骼肌条纹状肌中的血吸虫肉芽肿:组织学发现。
Mem Inst Oswaldo Cruz. 2020;115:e190383. doi: 10.1590/0074-02760190383. Epub 2020 May 11.
[一种从实验感染豚鼠中回收曼氏血吸虫的灌注技术]
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4
Schistosomotic choroiditis. II. Report of first case.血吸虫性脉络膜炎。II. 首例病例报告。
Br J Ophthalmol. 1985 Apr;69(4):300-2. doi: 10.1136/bjo.69.4.300.
5
Schistosomotic choroiditis. I. Funduscopic changes and differential diagnosis.血吸虫性脉络膜炎。一、眼底改变及鉴别诊断。
Br J Ophthalmol. 1985 Apr;69(4):294-9. doi: 10.1136/bjo.69.4.294.