Lopes Aline Ester da Silva Cruz, Araújo Larissa Fortunato, Levy Renata Bertazzi, Barreto Sandhi Maria, Giatti Luana
MSc. Dietitian, Postgraduate Program on Health and Nutrition, School of Nutrition, Universidade Federal de Ouro Preto (UFOP), Ouro Preto (MG), Brazil.
MSc. Dietitian and Adjunct Professor, School of Medicine, Universidade Federal do Ceará (UFC), Fortaleza (CE), and Research Group on Epidemiology of Chronic and Occupational Diseases (GERMINAL), School of Medicine, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte (MG), Brazil.
Sao Paulo Med J. 2019 Jul 15;137(2):169-176. doi: 10.1590/1516-3180.2018.0363070219.
There may be a direct association between consumption of ultra-processed foods and C-reactive protein (CRP) levels, under the assumption that the high glycemic index of these food products could stimulate the entire chronic inflammation cascade, along with an indirect association mediated by obesity. The types of food consumed, including ultra-processed products, strongly influence obesity, and are also associated with higher serum CRP levels.
Our aim was to investigate whether the caloric contribution of ultra-processed foods to diet is associated with CRP levels, independent of body mass index (BMI).
Cross-sectional analysis on the Longitudinal Study of Adult Health (ELSA-Brasil) baseline cohort (2008-2010).
Dietary information, obtained through a food frequency questionnaire, was used to estimate the percentage of energy contribution from ultra-processed food to individuals' total caloric intake. CRP levels were the response variable. Sex-specific associations were estimated using generalized linear models with gamma distribution and log-link function.
Ultra-processed food accounted for 20% of total energy intake. Among men, after adjustments for sociodemographic characteristics, there was no association between ultra-processed food intake and CRP levels. Among women, after adjustment for sociodemographic characteristics, smoking and physical activity, the highest tercile of ultra-processed food intake was associated with mean CRP levels that were 14% higher (95% confidence interval: 1.04-1.24) than those of the lowest tercile. However, after considering BMI, this association lost statistical significance.
Our findings suggest that the positive association of ultra-processed food consumption with CRP levels among women seems to be mediated by the presence of adiposity.
在假定这些食品的高血糖指数会刺激整个慢性炎症级联反应以及由肥胖介导的间接关联的情况下，超加工食品的消费与C反应蛋白（CRP）水平之间可能存在直接关联。所消费的食物类型，包括超加工产品，会强烈影响肥胖，并且还与较高的血清CRP水平相关。
我们的目的是研究超加工食品对饮食的热量贡献是否与CRP水平相关，而与体重指数（BMI）无关。
对成人健康纵向研究（ELSA - 巴西）基线队列（2008 - 2010年）进行横断面分析。
通过食物频率问卷获得的饮食信息用于估计超加工食品对个体总热量摄入的能量贡献百分比。CRP水平为反应变量。使用具有伽马分布和对数链接函数的广义线性模型估计性别特异性关联。
超加工食品占总能量摄入的20％。在男性中，在对社会人口统计学特征进行调整后，超加工食品摄入量与CRP水平之间没有关联。在女性中，在对社会人口统计学特征、吸烟和身体活动进行调整后，超加工食品摄入量最高的三分位数与平均CRP水平相关，该水平比最低三分位数高14％（95％置信区间：1.04 - 1.24）。然而，在考虑BMI后，这种关联失去了统计学意义。
我们的研究结果表明，女性中超加工食品消费与CRP水平之间的正相关似乎是由肥胖介导的。
