Gainey M A, Siegel J A, Smergel E M, Jara B J
Department of Radiology, St. Christopher's Hospital for Children, Philadelphia, PA 19133.
J Nucl Med. 1988 May;29(5):689-94.
The distribution of [111In]oxine-labeled leukocytes was studied by whole-body gamma camera imaging in nine pediatric patients. Images were obtained at approximately 24 hr after administration of the material. Organ distribution was estimated from stored data by manual region of interest assignment. Dosimetry estimates based on geometric mean and conjugate view absolute activity calculations showed close agreement in these patients. Leukocytes were distributed in liver, spleen and marrow. The mean percent uptakes +/- s.d. were: spleen, 31.2 +/- 18.3%; liver, 26.3 +/- 10.8%; and marrow, 14.2 +/- 5.7%. A significant portion (28.3 +/- 9.9%) of administered white cell activity was found outside these organs in the remainder of the body. Mean organ absorbed doses (rad/mCi) were: spleen, 115.0 +/- 84.8; liver, 13.9 +/- 7.8; marrow, 7.6 +/- 3.8; and total body 2.5 +/- 1.0. The mean organ absorbed doses (rad/dose administered) were: spleen, 13.7 +/- 10.6; liver, 1.48 +/- 0.62; marrow, 0.79 +/- 0.26; and total body, 0.28 +/- 0.09.
通过全身γ相机成像研究了9例儿科患者中[111In]奥克辛标记白细胞的分布情况。在给予该物质后约24小时获取图像。通过手动指定感兴趣区域从存储数据中估计器官分布。基于几何均值和共轭视图绝对活性计算的剂量学估计在这些患者中显示出密切一致性。白细胞分布于肝脏、脾脏和骨髓。平均摄取百分比±标准差分别为：脾脏，31.2±18.3%；肝脏，26.3±10.8%；骨髓，14.2±5.7%。在身体其余部位发现，给予的白细胞活性有相当一部分（28.3±9.9%）分布在这些器官之外。平均器官吸收剂量（rad/mCi）分别为：脾脏，115.0±84.8；肝脏，13.9±7.8；骨髓，7.6±3.8；全身，2.5±1.0。平均器官吸收剂量（rad/给予剂量）分别为：脾脏，13.7±10.6；肝脏，1.48±0.62；骨髓，0.79±0.26；全身，0.28±0.09。
