用铟-111 喹啉研究犬血小板的动力学、分布及破坏部位。

Kinetics, distribution, and sites of destruction of canine blood platelets with In-111 oxine.

作者信息

Lötter M G, Badenhorst P N, Heyns A D, Van Reenen O R, Pieters H, Minnaar P C

出版信息

J Nucl Med. 1980 Jan;21(1):36-40.

Abstract

In five normal dogs we have studied the survival, tissue distribution, and fate of autologous platelets labeled with indium- 111 oxine. The methods include blood sampling, computer-assisted scintigraphy, and whole-body profile scanning. Mean In- 111-platelet recovery in the circulation was 45 +/- 22.5 (s.d.) and survival 124.6 +/- 10.5 hr. Platelet survival curves fitted a linear function best. Initially platelets pooled rapidly in the spleen with a single exponential function, and at zero-time equilibrium (35 +/- 4)% of the injected In- 111 was located in this organ. Early hepatic uptake was also significant, and constituted (20 +/- 4)% of total-body radioactivity. As labeled platelets disappeared from the circulation, In- 111 activity in the spleen increased progressively and linearly to reach (59 +/- 9)% of the body activity at 120 hr. Hepatic radioactivity decreased with time but to a lesser extent than that of the heart. The results indicate that in the dog the major site of destruction of platelets is the spleen, with the liver playing a less important role.

摘要

在五只正常犬中，我们研究了用铟 - 111 草酸盐标记的自体血小板的存活情况、组织分布及转归。方法包括采血、计算机辅助闪烁扫描及全身轮廓扫描。循环中铟 - 111 血小板的平均回收率为 45±22.5（标准差），存活时间为 124.6±10.5 小时。血小板存活曲线最适合线性函数。最初，血小板以单一指数函数快速聚集于脾脏，在零时平衡时，注入的铟 - 111 中有（35±4）%位于该器官。早期肝脏摄取也很显著，占全身放射性的（20±4）%。随着标记血小板从循环中消失，脾脏中的铟 - 111 活性逐渐线性增加，在 120 小时时达到身体活性的（59±9）%。肝脏放射性随时间下降，但下降程度小于心脏。结果表明，在犬中，血小板破坏的主要部位是脾脏，肝脏起的作用较小。