Geist J R, Shupe R E, Kafrawy A H
Department of Radiology, University of Detroit, School of Dentistry, MI 48207.
J Oral Pathol. 1988 Jan;17(1):26-9. doi: 10.1111/j.1600-0714.1988.tb01500.x.
The effect of the radioprotector 2-mercaptopropionylglycine (MPG) in preventing the synthesis of radiation-induced osteodentin was examined. Fifty rats were exposed to single x-ray doses of between 3 and 19 Gy localized to the maxillary incisor growth centers. Half of the animals received an injection of MPG before irradiation while saline was administered to the other rats. MPG produced statistically significant reductions in the severity of osteodentin generation, but not its frequency, at some radiation levels. The nature of osteodentin and possible mechanisms of chemical radioprotection by MPG are discussed.
研究了辐射防护剂2-巯基丙酰甘氨酸（MPG）对预防辐射诱导的骨样牙本质合成的作用。将50只大鼠的上颌切牙生长中心局部暴露于3至19 Gy的单次X射线剂量下。一半动物在照射前注射MPG，另一半大鼠注射生理盐水。在某些辐射水平下，MPG在统计学上显著降低了骨样牙本质生成的严重程度，但未降低其发生率。讨论了骨样牙本质的性质以及MPG化学辐射防护的可能机制。
